In-Situ X-ray Imaging Of Sublimating Spin-Frozen Solutions.
X-ray micro-CT
dynamic imaging
freeze-drying
in-situ imaging
spin-freezing
Journal
Materials (Basel, Switzerland)
ISSN: 1996-1944
Titre abrégé: Materials (Basel)
Pays: Switzerland
ID NLM: 101555929
Informations de publication
Date de publication:
01 Jul 2020
01 Jul 2020
Historique:
received:
03
06
2020
revised:
22
06
2020
accepted:
29
06
2020
entrez:
8
7
2020
pubmed:
8
7
2020
medline:
8
7
2020
Statut:
epublish
Résumé
Spin-freeze-drying is a promising technique to enable long-term storage of pharmaceutical unit doses of aqueous drug solutions. To investigate the sublimation of the ice during the primary phase of freeze-drying, X-ray imaging can yield crucial temporally resolved information on the local dynamics. In this paper, we describe a methodology to investigate the sublimation front during single unit-dose freeze-drying using 4D in-situ X-ray imaging. Three spin-frozen samples of different solutions were imaged using this methodology and the process characteristics were analysed and reduced to two-dimensional feature maps.
Identifiants
pubmed: 32630310
pii: ma13132953
doi: 10.3390/ma13132953
pmc: PMC7378758
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fonds Wetenschappelijk Onderzoek
ID : 3G036518
Organisme : Fonds Wetenschappelijk Onderzoek
ID : 1S23417N
Organisme : Bijzonder Onderzoeksfonds UGent
ID : BOF.EXP.2017.000007
Organisme : Bijzonder Onderzoeksfonds UGent
ID : 01IO2518
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