In Vivo Assessment of Thermosensitive Liposomes for the Treatment of Port Wine Stains by Antifibrinolytic Site-Specific Pharmaco-Laser Therapy.
endovascular laser-tissue interactions
fluorescent thrombus staining
hyperthermia
intravital fluorescence microscopy
targeted drug delivery
thrombosis
tranexamic acid
vascular malformations
Journal
Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003
Informations de publication
Date de publication:
25 Jun 2020
25 Jun 2020
Historique:
received:
17
05
2020
revised:
13
06
2020
accepted:
22
06
2020
entrez:
8
7
2020
pubmed:
8
7
2020
medline:
8
7
2020
Statut:
epublish
Résumé
Antifibrinolytic site-specific pharmaco-laser therapy (SSPLT) is an experimental treatment modality for refractory port wine stains (PWS). Conceptually, antifibrinolytic drugs encapsulated in thermosensitive liposomes are delivered to thrombi that form in semi-photocoagulated PWS blood vessels after conventional laser treatment. Local release of antifibrinolytics is induced by mild hyperthermia, resulting in hyperthrombosis and complete occlusion of the target blood vessel (clinical endpoint). In this study, 20 thermosensitive liposomal formulations containing tranexamic acid (TA) were assayed for physicochemical properties, TA:lipid ratio, encapsulation efficiency, and endovesicular TA concentration. Two candidate formulations (DPPC:DSPE-PEG, DPPC:MPPC:DSPE-PEG) were selected based on optimal properties and analyzed for heat-induced TA release at body temperature (T), phase transition temperature (T
Identifiants
pubmed: 32630457
pii: pharmaceutics12060591
doi: 10.3390/pharmaceutics12060591
pmc: PMC7356038
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Stichting Technologische Wetenschappen
ID : 12064
Organisme : Academic Medical Center SKE Fund
ID : Technostarter # 20090812
Organisme : KWF Kankerbestrijding
ID : project # 10666
Organisme : National Natural Science Foundation of China
ID : 81872220
Organisme : Zhejiang Provincial Foreign Expert Program Grant
ID : *
Organisme : Zhejiang Provincial Key Natural Science Foundation of China
ID : #Z20H160031
Organisme : Grant for the establishment of the Jiaxing Key Laboratory for Photonanomedicine and Experimental Therapeutics
ID : *
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