Features of the Human Antibody Response against the Respiratory Syncytial Virus Surface Glycoprotein G.
G protein
antibody response
epitope
glycoprotein protein
recombinant proteins
respiratory syncytial virus (RSV)
Journal
Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355
Informations de publication
Date de publication:
25 Jun 2020
25 Jun 2020
Historique:
received:
22
05
2020
revised:
14
06
2020
accepted:
18
06
2020
entrez:
8
7
2020
pubmed:
8
7
2020
medline:
8
7
2020
Statut:
epublish
Résumé
Respiratory syncytial virus (RSV) infections are a major cause of serious respiratory disease in infants. RSV occurs as two major subgroups A and B, which mainly differ regarding the surface glycoprotein G. The G protein is important for virus attachment and G-specific antibodies can protect against infection. We expressed the surface-exposed part of A2 strain-derived G (A2-G) in baculovirus-infected insect cells and synthesized overlapping peptides spanning complete A2-G. The investigation of the natural IgG response of adult subjects during a period of one year showed that IgG antibodies (i) recognize G significantly stronger than the fusion protein F0, (ii) target mainly non-conformational, sequential peptide epitopes from the exposed conserved region but also buried peptides, and (iii) exhibit a scattered but constant recognition profile during the observation period. The IgG subclass reactivity profile (IgG
Identifiants
pubmed: 32630611
pii: vaccines8020337
doi: 10.3390/vaccines8020337
pmc: PMC7350215
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Austrian Science Fund FWF
ID : P 29398
Pays : Austria
Organisme : Austrian Science Fund
ID : F4605, P29398
Références
Am J Hyg. 1957 Nov;66(3):281-90
pubmed: 13478578
J Clin Microbiol. 1989 Feb;27(2):295-9
pubmed: 2915022
PLoS One. 2015 Feb 06;10(2):e0117204
pubmed: 25658330
Pharmacoeconomics. 2007;25(1):55-71
pubmed: 17192118
Hum Immunol. 2015 Jul;76(7):519-24
pubmed: 26074414
J Virol. 2018 Jan 17;92(3):
pubmed: 29118126
J Gen Virol. 1988 Jun;69 ( Pt 6):1229-39
pubmed: 3385405
Front Immunol. 2019 Nov 29;10:2778
pubmed: 31849961
J Allergy Clin Immunol. 2012 Dec;130(6):1418-20.e4
pubmed: 22867692
Allergy. 2019 Jan;74(1):40-52
pubmed: 30276826
Eur J Immunol. 1995 Mar;25(3):823-9
pubmed: 7705414
PLoS One. 2017 Apr 6;12(4):e0175384
pubmed: 28384263
J Virol. 1989 Nov;63(11):4767-76
pubmed: 2677404
FASEB J. 2012 Mar;26(3):1001-8
pubmed: 22121050
J Allergy Clin Immunol. 2015 May;135(5):1207-7.e1-11
pubmed: 25441634
PLoS Pathog. 2016 Apr 21;12(4):e1005554
pubmed: 27100289
J Clin Microbiol. 1986 Aug;24(2):304-6
pubmed: 3755731
Proc Soc Exp Biol Med. 1956 Jul;92(3):544-9
pubmed: 13359460
J Clin Microbiol. 1989 Mar;27(3):589-92
pubmed: 2715331
PLoS Pathog. 2018 Mar 6;14(3):e1006935
pubmed: 29509814
PLoS Pathog. 2018 Aug 24;14(8):e1007262
pubmed: 30142227
J Virol. 1987 Oct;61(10):3163-6
pubmed: 3305988
Proc Natl Acad Sci U S A. 1987 Aug;84(16):5625-9
pubmed: 2441388
J Virol. 2015 Aug;89(16):8193-205
pubmed: 26018164
Pediatrics. 1998 Sep;102(3):531-7
pubmed: 9724660
J Mol Recognit. 1998 Winter;11(1-6):49-51
pubmed: 10076805
J Clin Microbiol. 1987 Apr;25(4):748-50
pubmed: 3571485
Pediatr Infect Dis J. 2004 Jan;23(1 Suppl):S19-24
pubmed: 14730266
J Gen Virol. 2007 Oct;88(Pt 10):2719-23
pubmed: 17872524
Nat Commun. 2018 Jun 18;9(1):2382
pubmed: 29915220
Proc Natl Acad Sci U S A. 1985 Jun;82(12):4075-9
pubmed: 3858865
J Allergy Clin Immunol. 2020 Jun;145(6):1529-1534
pubmed: 32081759
J Med Virol. 1995 Oct;47(2):120-5
pubmed: 8830114
J Clin Microbiol. 1997 Jul;35(7):1656-60
pubmed: 9196168
Nat Rev Microbiol. 2019 Apr;17(4):233-245
pubmed: 30723301
Allergy. 2016 Dec;71(12):1728-1735
pubmed: 27444786
Sci Rep. 2017 Feb 10;7:42428
pubmed: 28186208
J Med Virol. 2000 Apr;60(4):468-74
pubmed: 10686032
PLoS One. 2014 Nov 04;9(11):e111483
pubmed: 25368998
Lancet. 2013 Mar 9;381(9869):861-73
pubmed: 23428115
J Virol. 1999 Jul;73(7):5637-45
pubmed: 10364313
Vaccine. 1997 Mar;15(4):423-32
pubmed: 9141214
Int Arch Allergy Immunol. 2007;142(2):133-44
pubmed: 17057411
N Engl J Med. 2005 Apr 28;352(17):1749-59
pubmed: 15858184
J Allergy Clin Immunol. 2007 Feb;119(2):351-8
pubmed: 17140649
Clin Microbiol Rev. 2000 Jan;13(1):1-15, table of contents
pubmed: 10627488
Front Immunol. 2019 Mar 22;10:548
pubmed: 30967872
Antiviral Res. 1995 Dec;28(4):303-15
pubmed: 8669890
EBioMedicine. 2014 Nov 18;2(1):64-70
pubmed: 26137535
Am J Respir Crit Care Med. 2018 Dec 15;198(12):1490-1499
pubmed: 30134114