Squalamine and Aminosterol Mimics Inhibit the Peptidoglycan Glycosyltransferase Activity of PBP1b.
Lipid II
PBP1b
cationic aminosterols
peptidoglycan
squalamine
Journal
Antibiotics (Basel, Switzerland)
ISSN: 2079-6382
Titre abrégé: Antibiotics (Basel)
Pays: Switzerland
ID NLM: 101637404
Informations de publication
Date de publication:
02 Jul 2020
02 Jul 2020
Historique:
received:
02
06
2020
revised:
24
06
2020
accepted:
30
06
2020
entrez:
8
7
2020
pubmed:
8
7
2020
medline:
8
7
2020
Statut:
epublish
Résumé
Peptidoglycan (PG) is an essential polymer of the bacterial cell wall and a major antibacterial target. Its synthesis requires glycosyltransferase (GTase) and transpeptidase enzymes that, respectively, catalyze glycan chain elongation and their cross-linking to form the protective sacculus of the bacterial cell. The GTase domain of bifunctional penicillin-binding proteins (PBPs) of class A, such as
Identifiants
pubmed: 32630634
pii: antibiotics9070373
doi: 10.3390/antibiotics9070373
pmc: PMC7400108
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Fonds De La Recherche Scientifique - FNRS
ID : CDR J.0030.18, FRIA 1.E.038.17
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