IL-6 Trans-Signaling in the Brain Influences the Metabolic Phenotype of the 3xTg-AD Mouse Model of Alzheimer's Disease.
Alzheimer Disease
/ genetics
Amyloid
/ metabolism
Animals
Brain
/ metabolism
Cytokine Receptor gp130
/ genetics
Disease Models, Animal
Female
Glial Fibrillary Acidic Protein
/ genetics
Hybridization, Genetic
Interleukin-6
/ metabolism
Male
Mice
Mice, Inbred C57BL
Mice, Inbred Strains
Mice, Transgenic
Phenotype
Signal Transduction
Weight Gain
Alzheimer’s disease
IL-6
IL-6 trans-signaling
body weight
high-fat diet
insulin
leptin
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
02 07 2020
02 07 2020
Historique:
received:
28
05
2020
revised:
30
06
2020
accepted:
01
07
2020
entrez:
8
7
2020
pubmed:
8
7
2020
medline:
9
3
2021
Statut:
epublish
Résumé
Alzheimer's disease (AD) is a neurodegenerative disorder that causes the most prevalent dementia in the elderly people. Obesity and insulin resistance, which may cause major health problems
Identifiants
pubmed: 32630818
pii: cells9071605
doi: 10.3390/cells9071605
pmc: PMC7407279
pii:
doi:
Substances chimiques
Amyloid
0
Glial Fibrillary Acidic Protein
0
Interleukin-6
0
glial fibrillary astrocytic protein, mouse
0
interleukin-6, mouse
0
Cytokine Receptor gp130
133483-10-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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