Understanding Normal and Malignant Human Hematopoiesis Using Next-Generation Humanized Mice.
human hematopoiesis
human immunity
humanized mouse
leukemia
xenograft
Journal
Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
09
08
2019
revised:
12
06
2020
accepted:
14
06
2020
pubmed:
8
7
2020
medline:
17
3
2021
entrez:
8
7
2020
Statut:
ppublish
Résumé
Rodent models for human diseases contribute significantly to understanding human physiology and pathophysiology. However, given the accelerating pace of drug development, there is a crucial need for in vivo preclinical models of human biology and pathology. The humanized mouse is one tool to bridge the gap between traditional animal models and the clinic. The development of immunodeficient mouse strains with high-level engraftment of normal and diseased human immune/hematopoietic cells has made in vivo functional characterization possible. As a patient-derived xenograft (PDX) model, humanized mice functionally correlate putative mechanisms with in vivo behavior and help to reveal pathogenic mechanisms. Combined with single-cell genomics, humanized mice can facilitate functional precision medicine such as risk stratification and individually optimized therapeutic approaches.
Identifiants
pubmed: 32631635
pii: S1471-4906(20)30128-9
doi: 10.1016/j.it.2020.06.004
pmc: PMC7395895
mid: NIHMS1605400
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
706-720Subventions
Organisme : NIH HHS
ID : R24 OD026440
Pays : United States
Organisme : NCI NIH HHS
ID : R37 CA237307
Pays : United States
Organisme : NIDDK NIH HHS
ID : U01 DK104218
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI132963
Pays : United States
Organisme : NIDDK NIH HHS
ID : UC4 DK104218
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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