Neuropathologic features associated with basal forebrain atrophy in Alzheimer disease.
Journal
Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060
Informations de publication
Date de publication:
08 09 2020
08 09 2020
Historique:
received:
26
11
2019
accepted:
09
03
2020
pubmed:
8
7
2020
medline:
23
10
2020
entrez:
8
7
2020
Statut:
ppublish
Résumé
To study the neuropathologic correlates of cholinergic basal forebrain (BF) atrophy as determined using antemortem MRI in the Alzheimer disease (AD) spectrum. We determined associations between BF volume from antemortem MRI brain scans and postmortem assessment of neuropathologic features, including neuritic plaques, neurofibrillary tangles (NFTs), Lewy body (LB) pathology, and TDP-43, in 64 cases of the Alzheimer's Disease Neuroimaging Initiative cohort. For comparison, we assessed neuropathologic features associated with hippocampal and parahippocampal gyrus atrophy. In addition to region of interest-based analysis, we determined the association of neuropathologic features with whole brain gray matter volume using regionally unbiased voxel-based volumetry. BF atrophy was associated with Thal amyloid phases (95% confidence interval [CI] -0.49 to -0.01, These findings indicate that neuropathologic correlates of regional atrophy differ substantially between different brain regions that are typically involved in AD-related neurodegeneration, including different susceptibilities to common comorbid pathologies.
Identifiants
pubmed: 32631924
pii: WNL.0000000000010192
doi: 10.1212/WNL.0000000000010192
pmc: PMC7538215
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1301-e1311Subventions
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG024904
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001420
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG066462
Pays : United States
Organisme : CIHR
Pays : Canada
Investigateurs
Michael Weiner
(M)
Paul Aisen
(P)
Ronald Petersen
(R)
Clifford R. Jack
(CR)
William Jagust
(W)
John Q. Trojanowki
(JQ)
Arthur W. Toga
(AW)
Laurel Beckett
(L)
Robert C. Green
(RC)
Andrew J. Saykin
(AJ)
John Morris
(J)
Enchi Liu
(E)
Robert C. Green
(RC)
Tom Montine
(T)
Ronald Petersen
(R)
Paul Aisen
(P)
Anthony Gamst
(A)
Ronald G. Thomas
(RG)
Michael Donohue
(M)
Sarah Walter
(S)
Devon Gessert
(D)
Tamie Sather
(T)
Laurel Beckett
(L)
Danielle Harvey
(D)
Anthony Gamst
(A)
Michael Donohue
(M)
John Kornak
(J)
Clifford R. Jack
(CR)
Anders Dale
(A)
Matthew Bernstein
(M)
Joel Felmlee
(J)
Nick Fox
(N)
Paul Thompson
(P)
Norbert Schuff
(N)
Gene Alexander
(G)
Charles DeCarli
(C)
William Jagust
(W)
Dan Bandy
(D)
Robert A. Koeppe
(RA)
Norm Foster
(N)
Eric M. Reiman
(EM)
Kewei Chen
(K)
Chet Mathis
(C)
John Morris
(J)
Nigel J. Cairns
(NJ)
Lisa Taylor-Reinwald
(L)
J Q Trojanowki
(JQ)
Les Shaw
(L)
Virginia M Y Lee
(VMY)
Magdalena Korecka
(M)
Arthur W. Toga
(AW)
Karen Crawford
(K)
Scott Neu
(S)
Andrew J. Saykin
(AJ)
Tatiana M. Foroud
(TM)
Steven Potkin
(S)
Li Shen
(L)
Zaven Kachaturian
(Z)
Richard Frank
(R)
Peter J. Snyder
(PJ)
Susan Molchan
(S)
Jeffrey Kaye
(J)
Joseph Quinn
(J)
Betty Lind
(B)
Sara Dolen
(S)
Lon S. Schneider
(LS)
Sonia Pawluczyk
(S)
Bryan M. Spann
(BM)
James Brewer
(J)
Helen Vanderswag
(H)
Judith L. Heidebrink
(JL)
Joanne L. Lord
(JL)
Ronald Petersen
(R)
Kris Johnson
(K)
Rachelle S. Doody
(RS)
Javier Villanueva-Meyer
(J)
Munir Chowdhury
(M)
Yaakov Stern
(Y)
Lawrence S. Honig
(LS)
Karen L. Bell
(KL)
John C. Morris
(JC)
Beau Ances
(B)
Maria Carroll
(M)
Sue Leon
(S)
Mark A. Mintun
(MA)
Stacy Schneider
(S)
Daniel Marson
(D)
Randall Griffith
(R)
David Clark
(D)
Hillel Grossman
(H)
Effie Mitsis
(E)
Aliza Romirowsky
(A)
Leyla deToledo-Morrell
(L)
Raj C. Shah
(RC)
Ranjan Duara
(R)
Daniel Varon
(D)
Peggy Roberts
(P)
Marilyn Albert
(M)
Chiadi Onyike
(C)
Stephanie Kielb
(S)
Henry Rusinek
(H)
Mony J de Leon
(MJ)
Lidia Glodzik
(L)
Susan De Santi
(S)
P. Murali Doraiswamy
(PM)
Jeffrey R. Petrella
(JR)
R. Edward Coleman
(RE)
Steven E. Arnold
(SE)
Jason H. Karlawish
(JH)
David Wolk
(D)
Charles D. Smith
(CD)
Greg Jicha
(G)
Peter Hardy
(P)
Oscar L. Lopez
(OL)
MaryAnn Oakley
(M)
Donna M. Simpson
(DM)
Anton P. Porsteinsson
(AP)
Bonnie S. Goldstein
(BS)
Kim Martin
(K)
Kelly M. Makino
(KM)
M. Saleem Ismail
(MS)
Connie Brand
(C)
Ruth A. Mulnard
(RA)
Gaby Thai
(G)
Catherine Mc-Adams-Ortiz
(C)
Kyle Womack
(K)
Dana Mathews
(D)
Mary Quiceno
(M)
Ramon Diaz-Arrastia
(R)
Richard King
(R)
Myron Weiner
(M)
Kristen Martin-Cook
(K)
Michael DeVous
(M)
Allan I. Levey
(AI)
James J. Lah
(JJ)
Janet S. Cellar
(JS)
Jeffrey M. Burns
(JM)
Heather S. Anderson
(HS)
Russell H. Swerdlow
(RH)
Liana Apostolova
(L)
Po H. Lu
(PH)
George Bartzokis
(G)
Daniel H.S. Silverman
(DH)
Neill R Graff-Radford
(NR)
Francine Parfitt
(F)
Heather Johnson
(H)
Martin R. Farlow
(MR)
Ann Marie Hake
(AM)
Brandy R. Matthews
(BR)
Scott Herring
(S)
Christopher H. van Dyck
(CH)
Richard E. Carson
(RE)
Martha G. MacAvoy
(MG)
Howard Chertkow
(H)
Howard Bergman
(H)
Chris Hosein
(C)
Sandra Black
(S)
Bojana Stefanovic
(B)
Curtis Caldwell
(C)
Ging-Yuek Robin Hsiung
(GR)
Howard Feldman
(H)
Benita Mudge
(B)
Michele Assaly
(M)
Andrew Kertesz
(A)
John Rogers
(J)
Dick Trost
(D)
Charles Bernick
(C)
Donna Munic
(D)
Diana Kerwin
(D)
Marek-Marsel Mesulam
(MM)
Kristina Lipowski
(K)
Chuang-Kuo Wu
(CK)
Nancy Johnson
(N)
Carl Sadowsky
(C)
Walter Martinez
(W)
Teresa Villena
(T)
Raymond Scott Turner
(R)
Kathleen Johnson
(K)
Brigid Reynolds
(B)
Reisa A. Sperling
(RA)
Keith A. Johnson
(KA)
Gad Marshall
(G)
Meghan Frey
(M)
Jerome Yesavage
(J)
Joy L. Taylor
(JL)
Barton Lane
(B)
Allyson Rosen
(A)
Jared Tinklenberg
(J)
Marwan Sabbagh
(M)
Christine Belden
(C)
Sandra Jacobson
(S)
Neil Kowall
(N)
Ronald Killiany
(R)
Andrew E. Budson
(AE)
Alexander Norbash
(A)
Patricia Lynn Johnson
(PL)
Thomas O. Obisesan
(TO)
Saba Wolday
(S)
Salome K. Bwayo
(SK)
Alan Lerner
(A)
Leon Hudson
(L)
Paula Ogrocki
(P)
Evan Fletcher
(E)
Owen Carmichael
(O)
John Olichney
(J)
Charles DeCarli
(C)
Smita Kittur
(S)
Michael Borrie
(M)
T-Y Lee
(TY)
Rob Bartha
(R)
Sterling Johnson
(S)
Sanjay Asthana
(S)
Cynthia M. Carlsson
(CM)
Steven G. Potkin
(SG)
Adrian Preda
(A)
Dana Nguyen
(D)
Pierre Tariot
(P)
Adam Fleisher
(A)
Stephanie Reeder
(S)
Vernice Bates
(V)
Horacio Capote
(H)
Michelle Rainka
(M)
Douglas W. Scharre
(DW)
Maria Kataki
(M)
Earl A. Zimmerman
(EA)
Dzintra Celmins
(D)
Alice D. Brown
(AD)
Godfrey D. Pearlson
(GD)
Karen Blank
(K)
Karen Anderson
(K)
Andrew J. Saykin
(AJ)
Robert B. Santulli
(RB)
Eben S. Schwartz
(ES)
Kaycee M. Sink
(KM)
Jeff D. Williamson
(JD)
Pradeep Garg
(P)
Franklin Watkins
(F)
Brian R. Ott
(BR)
Henry Querfurth
(H)
Geoffrey Tremont
(G)
Stephen Salloway
(S)
Paul Malloy
(P)
Stephen Correia
(S)
Howard J. Rosen
(HJ)
Bruce L. Miller
(BL)
Jacobo Mintzer
(J)
Crystal Flynn Longmire
(CF)
Kenneth Spicer
(K)
Elizabether Finger
(E)
Irina Rachinsky
(I)
John Rogers
(J)
Andrew Kertesz
(A)
Dick Drost
(D)
Nunzio Pomara
(N)
Raymundo Hernando
(R)
Antero Sarrael
(A)
Susan K. Schultz
(SK)
Laura L. Boles Ponto
(LL)
Hyungsub Shim
(H)
Karen Elizabeth Smith
(KE)
Norman Relkin
(N)
Gloria Chaing
(G)
Lisa Raudin
(L)
Amanda Smith
(A)
Kristin Fargher
(K)
Balebail Ashok Raj
(BA)
Informations de copyright
Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.
Références
J Neurol Neurosurg Psychiatry. 2017 Nov;88(11):908-916
pubmed: 28473626
Ann Neurol. 2018 Nov;84(5):741-753
pubmed: 30246887
Neurology. 2008 Sep 2;71(10):743-9
pubmed: 18765650
J Alzheimers Dis. 2018;64(2):483-496
pubmed: 29865073
Acta Neuropathol. 2014;127(6):811-24
pubmed: 24659241
Lancet Neurol. 2014 Jun;13(6):614-29
pubmed: 24849862
Brain Imaging Behav. 2012 Dec;6(4):517-27
pubmed: 22644789
Acta Neuropathol. 2011 Jul;122(1):49-60
pubmed: 21533854
Neurobiol Aging. 2017 Aug;56:172-179
pubmed: 28552181
Acta Neuropathol. 2012 Jan;123(1):1-11
pubmed: 22101365
Neurobiol Aging. 2017 May;53:83-92
pubmed: 28236716
Cereb Cortex. 2017 Jul 1;27(7):3553-3567
pubmed: 27312991
Brain. 2016 Nov 1;139(11):2983-2993
pubmed: 27694152
Alzheimers Dement. 2015 Jul;11(7):815-22
pubmed: 26194314
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
Hum Brain Mapp. 2003 Aug;19(4):224-47
pubmed: 12874777
Alzheimers Dement. 2015 Feb;11(2):139-50
pubmed: 25620800
Neurology. 2003 Aug 26;61(4):487-92
pubmed: 12939422
Alzheimers Dement. 2017 Aug;13(8):893-902
pubmed: 28238738
Biol Psychiatry. 2012 May 1;71(9):805-13
pubmed: 21816388
J Alzheimers Dis. 2017;57(2):575-601
pubmed: 28282807
Ann Neurol. 2005 Jun;57(6):896-903
pubmed: 15929035
Ann Neurol. 2004 Jun;55(6):815-28
pubmed: 15174015
Brain Imaging Behav. 2012 Dec;6(4):502-16
pubmed: 22782295
Brain. 2019 Jun 1;142(6):1503-1527
pubmed: 31039256
Curr Geriatr Rep. 2018 Mar;7(1):1-11
pubmed: 29503795
Alzheimers Dement. 2014 Oct;10(5 Suppl):S344-53
pubmed: 24418052
Neuroscience. 2000;95(3):721-5
pubmed: 10670438
J Neuropathol Exp Neurol. 2016 Jun;75(6):516-26
pubmed: 27105663
Neurobiol Aging. 2019 May;77:104-111
pubmed: 30784812
Neuroimage Clin. 2014 Nov 27;7:105-13
pubmed: 25610772
Brain. 2015 Jun;138(Pt 6):1722-37
pubmed: 25732182
Ann Neurol. 2015 Nov;78(5):697-709
pubmed: 26224156
Neurology. 2008 May 6;70(19 Pt 2):1850-7
pubmed: 18401022
Brain. 2012 Oct;135(Pt 10):3015-25
pubmed: 23012333
Alzheimer Dis Assoc Disord. 2004 Oct-Dec;18(4):190-5
pubmed: 15592129
Biol Psychiatry. 2012 May 1;71(9):760-1
pubmed: 22482884
Nat Commun. 2016 Nov 04;7:13249
pubmed: 27811848
Lancet Neurol. 2017 Nov;16(11):917-924
pubmed: 28919059
Neurology. 1984 Jul;34(7):939-44
pubmed: 6610841
Neuroimage. 2007 Oct 15;38(1):95-113
pubmed: 17761438
J Neuropathol Exp Neurol. 2008 Apr;67(4):309-18
pubmed: 18379437
Behav Brain Res. 2016 Sep 15;311:54-69
pubmed: 27185734
Acta Neuropathol. 2015 Apr;129(4):527-40
pubmed: 25633602
AJNR Am J Neuroradiol. 2017 May;38(5):961-965
pubmed: 28279988
J Neuropathol Exp Neurol. 2016 May;75(5):397-407
pubmed: 26971127
Prog Brain Res. 1996;109:285-97
pubmed: 9009717
J Chem Neuroanat. 2003 Dec;26(4):233-42
pubmed: 14729126
J Alzheimers Dis. 2014;40(3):687-700
pubmed: 24503619