Clinicopathological study of blue nevi of the gastrointestinal (GI) tract: first case series.
gastrointestinal diseases
gastrointestinal neoplasms
pathology, surgical
Journal
Journal of clinical pathology
ISSN: 1472-4146
Titre abrégé: J Clin Pathol
Pays: England
ID NLM: 0376601
Informations de publication
Date de publication:
Mar 2021
Mar 2021
Historique:
received:
13
05
2020
revised:
10
06
2020
accepted:
13
06
2020
pubmed:
8
7
2020
medline:
16
3
2021
entrez:
8
7
2020
Statut:
ppublish
Résumé
Blue nevus (BN) is a benign melanocytic proliferation that is typically cutaneous. Extracutaneous BN is infrequent and is reported in the mucosa of various organs. Gastrointestinal (GI) tract BN is rare. Here, we describe the clinicopathological findings of the largest series of GI tract BNs. A search of our Pathology Data System (1984-2019) identified six GI tract blue nevi. Clinical information, pathology reports and available H&E-stained section slides were reviewed. Lesions predominated in the middle-aged adults (mean 54, range 27-80) with a slight female predominance (66%). Most cases arose in the rectum and colon (83%), with one gastric lesion (17%). Four cases were identified during endoscopic examination performed either for screening or for unrelated symptoms (66%). Two patients presented with rectal bleeding (33%) unassociated with the BN. Endoscopically, most lesions appeared as superficial hyperpigmented areas (83%). One case was described as abnormal mucosa (17%). Microscopically, the mucosa was involved in all of the cases (100%). One case showed submucosal extension in addition to the mucosal component (17%). Lesions showed a proliferation of bland spindle cells with abundant granular pigment. No nuclear atypia or mitoses were identified. Immunostains showed immunoreactivity for melanocytic markers. Follow-up information available for five patients showed no recurrences to date (mean follow-up 1 year). BN is a benign melanocytic proliferation. It is important to be aware of the occurrence of such lesions outside of the skin and consider the possibility of BN when pigmented lesions are encountered in the GI tract.
Identifiants
pubmed: 32631943
pii: jclinpath-2020-206757
doi: 10.1136/jclinpath-2020-206757
pmc: PMC9281536
mid: NIHMS1820757
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
167-170Subventions
Organisme : NCI NIH HHS
ID : T32 CA193145
Pays : United States
Informations de copyright
© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
J Oral Pathol Med. 1990 May;19(5):197-201
pubmed: 2359037
Am J Clin Pathol. 1988 Nov;90(5):530-5
pubmed: 3177272
Pathologica. 1992 Jul-Aug;84(1092):547-50
pubmed: 1491897
Pathol Res Pract. 2015 Aug;211(8):625-7
pubmed: 26008779
Am J Surg Pathol. 1996 Mar;20(3):259-72
pubmed: 8772778
J Dermatol Surg Oncol. 1984 Aug;10(8):596-8
pubmed: 6747071
Clin Lab Med. 2017 Sep;37(3):401-415
pubmed: 28802492
Arch Pathol Lab Med. 2011 Mar;135(3):327-36
pubmed: 21366456
ACG Case Rep J. 2016 Dec 7;3(4):e168
pubmed: 28008401
Exp Clin Endocrinol Diabetes. 2019 Feb;127(2-03):156-164
pubmed: 30428497
Ann Diagn Pathol. 2011 Apr;15(2):128-30
pubmed: 20952298
Dermatopathology (Basel). 2015 Dec 15;2(3):67-70
pubmed: 27047937
Nature. 2009 Jan 29;457(7229):599-602
pubmed: 19078957
Arch Pathol Lab Med. 2006 Apr;130(4):552-7
pubmed: 16594751
Head Neck. 2001 Jun;23(6):506-9
pubmed: 11360315
Iran J Pathol. 2015 Summer;10(3):248-52
pubmed: 26351493
Int J Cancer. 2004 Sep 20;111(5):705-10
pubmed: 15252839
J Cutan Pathol. 2010 Jan;37(1):102-4
pubmed: 19615001
J Am Acad Dermatol. 2007 May;56(5):828-34
pubmed: 17349716
Am J Surg Pathol. 2014 Jan;38(1):94-105
pubmed: 24145644
Hum Pathol. 2011 Jan;42(1):136-40
pubmed: 21056896