Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity.
Animals
Brain
/ metabolism
Cell Line
Disease Models, Animal
Dopamine
/ metabolism
Dopaminergic Neurons
/ metabolism
Female
GTP Phosphohydrolases
/ metabolism
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
/ genetics
Mice
Mice, Knockout
Mutation
Neurodegenerative Diseases
/ drug therapy
Parkinson Disease
/ metabolism
Phenotype
Pilot Projects
Protein Kinase Inhibitors
/ pharmacology
Rats
Rats, Wistar
Substantia Nigra
GTPase
LRRK2
Rab
kinase
neurodegeneration
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
21 07 2020
21 07 2020
Historique:
pubmed:
8
7
2020
medline:
15
9
2020
entrez:
8
7
2020
Statut:
ppublish
Résumé
Mutations in
Identifiants
pubmed: 32631998
pii: 1922184117
doi: 10.1073/pnas.1922184117
pmc: PMC7382283
doi:
Substances chimiques
Protein Kinase Inhibitors
0
LRRK2 protein, rat
EC 2.7.11.1
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
EC 2.7.11.1
GTP Phosphohydrolases
EC 3.6.1.-
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
17296-17307Subventions
Organisme : NINDS NIH HHS
ID : R01 NS064934
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS091719
Pays : United States
Organisme : NINDS NIH HHS
ID : R33 NS097643
Pays : United States
Informations de copyright
Copyright © 2020 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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