Functionally distinct Purkinje cell types show temporal precision in encoding locomotion.
Purkinje cells
central pattern generator
cerebellum
locomotion
zebrafish
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
21 07 2020
21 07 2020
Historique:
pubmed:
8
7
2020
medline:
15
9
2020
entrez:
8
7
2020
Statut:
ppublish
Résumé
Purkinje cells, the principal neurons of cerebellar computations, are believed to comprise a uniform neuronal population of cells, each with similar functional properties. Here, we show an undiscovered heterogeneity of adult zebrafish Purkinje cells, revealing the existence of anatomically and functionally distinct cell types. Dual patch-clamp recordings showed that the cerebellar circuit contains all Purkinje cell types that cross-communicate extensively using chemical and electrical synapses. Further activation of spinal central pattern generators (CPGs) revealed unique phase-locked activity from each Purkinje cell type during the locomotor cycle. Thus, we show intricately organized Purkinje cell networks in the adult zebrafish cerebellum that encode the locomotion rhythm differentially, and we suggest that these organizational properties may also apply to other cerebellar functions.
Identifiants
pubmed: 32632015
pii: 2005633117
doi: 10.1073/pnas.2005633117
pmc: PMC7382291
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
17330-17337Informations de copyright
Copyright © 2020 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
The authors declare no competing interest.
Références
Nat Rev Neurosci. 2015 Feb;16(2):79-93
pubmed: 25601779
Trends Cogn Sci. 1998 Sep 1;2(9):338-47
pubmed: 21227230
Science. 1988 Nov 4;242(4879):773-7
pubmed: 2847315
Neuron. 2008 Jun 12;58(5):775-88
pubmed: 18549788
Nat Biotechnol. 2018 Oct 15;:
pubmed: 30320766
J Physiol. 1988 Nov;405:1-37
pubmed: 3076600
J Physiol. 1988 Jul;401:399-415
pubmed: 3171993
J Physiol. 1988 Jun;400:425-45
pubmed: 3418533
Neuron. 2016 Jul 20;91(2):312-9
pubmed: 27346533
Dev Growth Differ. 2012 Apr;54(3):373-89
pubmed: 22524607
Eur J Neurosci. 2013 Sep;38(6):2917-32
pubmed: 23731348
Nat Rev Neurosci. 2009 Sep;10(9):670-81
pubmed: 19693030
J Neurosci. 2010 Dec 15;30(50):16983-92
pubmed: 21159968
Elife. 2017 May 25;6:
pubmed: 28541889
Neuron. 2016 Apr 6;90(1):86-100
pubmed: 27021171
J Neurosci. 2013 Jun 26;33(26):10875-86
pubmed: 23804107
Nat Rev Neurosci. 2005 Apr;6(4):297-311
pubmed: 15803161
Proc Natl Acad Sci U S A. 2004 Oct 26;101(43):15482-7
pubmed: 15489269
Curr Biol. 2015 May 4;25(9):1157-65
pubmed: 25843032
Elife. 2015 Sep 29;4:
pubmed: 26416140
Science. 2012 Oct 5;338(6103):128-32
pubmed: 22983708
Brain. 2006 Feb;129(Pt 2):290-2
pubmed: 16434422
Neuroscience. 1994 Aug;61(4):935-54
pubmed: 7530818
Nat Neurosci. 2018 Oct;21(10):1350-1358
pubmed: 30250262
Neuron. 2013 Oct 30;80(3):807-15
pubmed: 24183029
Curr Opin Neurobiol. 2015 Aug;33:150-5
pubmed: 25884963
Neuropharmacology. 2015 Jan;88:10-23
pubmed: 25239808
Elife. 2018 Apr 16;7:
pubmed: 29659351
Neuron. 2014 Aug 6;83(3):518-32
pubmed: 25102558
Neuron. 2016 Jun 1;90(5):1043-56
pubmed: 27133465
Curr Opin Neurobiol. 2011 Aug;21(4):616-22
pubmed: 21684147
Nature. 2011 Dec 25;481(7382):502-5
pubmed: 22198670
Elife. 2014 May 07;3:e02536
pubmed: 24843004
Neuron. 2015 Aug 19;87(4):840-52
pubmed: 26291165
Science. 2019 Jan 18;363(6424):
pubmed: 30655412
J Neurosci Res. 2018 Sep;96(9):1476-1489
pubmed: 29319237
Nat Rev Neurosci. 2008 Apr;9(4):304-13
pubmed: 18319727
Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11846-51
pubmed: 25002482
Nat Neurosci. 2009 Apr;12(4):463-73
pubmed: 19287389
Nature. 2012 Aug 30;488(7413):647-51
pubmed: 22763451
Brain Struct Funct. 2015 Nov;220(6):3513-36
pubmed: 25139623
Elife. 2019 Jan 25;8:
pubmed: 30681408
Curr Opin Neurol. 2009 Aug;22(4):419-29
pubmed: 19421057
Annu Rev Neurosci. 2009;32:413-34
pubmed: 19555291
Prog Neurobiol. 2006 Feb-Apr;78(3-5):272-303
pubmed: 16759785
Dev Biol. 2009 Jun 15;330(2):406-26
pubmed: 19371731
Nat Neurosci. 2019 Jun;22(6):950-962
pubmed: 31036947
Science. 1976 Sep 24;193(4259):1256-8
pubmed: 785600
Front Neural Circuits. 2014 Dec 19;8:147
pubmed: 25565973
J Neurosci. 2019 May 15;39(20):3948-3969
pubmed: 30862666
Cerebellum. 2014 Feb;13(1):151-77
pubmed: 23996631