T cell antigen discovery.
Journal
Nature methods
ISSN: 1548-7105
Titre abrégé: Nat Methods
Pays: United States
ID NLM: 101215604
Informations de publication
Date de publication:
08 2021
08 2021
Historique:
received:
18
12
2019
accepted:
18
05
2020
pubmed:
8
7
2020
medline:
21
9
2021
entrez:
8
7
2020
Statut:
ppublish
Résumé
T cells respond to threats in an antigen-specific manner using T cell receptors (TCRs) that recognize short peptide antigens presented on major histocompatibility complex (MHC) proteins. The TCR-peptide-MHC interaction mediated between a T cell and its target cell dictates its function and thereby influences its role in disease. A lack of approaches for antigen discovery has limited the fundamental understanding of the antigenic landscape of the overall T cell response. Recent advances in high-throughput sequencing, mass cytometry, microfluidics and computational biology have led to a surge in approaches to address the challenge of T cell antigen discovery. Here, we summarize the scope of this challenge, discuss in depth the recent exciting work and highlight the outstanding questions and remaining technical hurdles in this field.
Identifiants
pubmed: 32632239
doi: 10.1038/s41592-020-0867-z
pii: 10.1038/s41592-020-0867-z
doi:
Substances chimiques
Antigens
0
Receptors, Antigen, T-Cell
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
873-880Informations de copyright
© 2020. Springer Nature America, Inc.
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