Intrinsic network architecture predicts the effects elicited by intracranial electrical stimulation of the human brain.
Journal
Nature human behaviour
ISSN: 2397-3374
Titre abrégé: Nat Hum Behav
Pays: England
ID NLM: 101697750
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
21
06
2019
accepted:
04
06
2020
pubmed:
8
7
2020
medline:
2
12
2020
entrez:
8
7
2020
Statut:
ppublish
Résumé
Intracranial electrical stimulation (iES) of the human brain has long been known to elicit a remarkable variety of perceptual, motor and cognitive effects, but the functional-anatomical basis of this heterogeneity remains poorly understood. We conducted a whole-brain mapping of iES-elicited effects, collecting first-person reports following iES at 1,537 cortical sites in 67 participants implanted with intracranial electrodes. We found that intrinsic network membership and the principal gradient of functional connectivity strongly predicted the type and frequency of iES-elicited effects in a given brain region. While iES in unimodal brain networks at the base of the cortical hierarchy elicited frequent and simple effects, effects became increasingly rare, heterogeneous and complex in heteromodal and transmodal networks higher in the hierarchy. Our study provides a comprehensive exploration of the relationship between the hierarchical organization of intrinsic functional networks and the causal modulation of human behaviour and experience with iES.
Identifiants
pubmed: 32632334
doi: 10.1038/s41562-020-0910-1
pii: 10.1038/s41562-020-0910-1
pmc: PMC7572705
mid: NIHMS1614533
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1039-1052Subventions
Organisme : NIMH NIH HHS
ID : P50 MH109429
Pays : United States
Organisme : NIMH NIH HHS
ID : R00 MH103479
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH116914
Pays : United States
Organisme : CIHR
Pays : Canada
Commentaires et corrections
Type : CommentIn
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