Hepatoblastoma: current knowledge and promises from preclinical studies.
Hepatoblastoma (HB)
Yap
mTORC1
therapeutic strategies
β-catenin
Journal
Translational gastroenterology and hepatology
ISSN: 2415-1289
Titre abrégé: Transl Gastroenterol Hepatol
Pays: China
ID NLM: 101683450
Informations de publication
Date de publication:
2020
2020
Historique:
received:
09
09
2019
accepted:
12
11
2019
entrez:
8
7
2020
pubmed:
8
7
2020
medline:
8
7
2020
Statut:
epublish
Résumé
The survival rate for patients with metastatic hepatoblastoma (HB) is steadily increased in the last thirty years from 27% to 79%. These achievements result from accurate risk stratification and effective chemotherapy and surgical care. However, patients with poor prognosis require more effective therapies. Recent years have witnessed new insights on the biology of HB, setting the stage for molecular classification and new targets of therapy. We review here the molecular pathology of HB, focusing on the driver genes involved in the process of oncogenesis and the identification of novel targets. We also address the role of
Identifiants
pubmed: 32632393
doi: 10.21037/tgh.2019.12.03
pii: tgh-05-2019.12.03
pmc: PMC7063515
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
42Informations de copyright
2020 Translational Gastroenterology and Hepatology. All rights reserved.
Déclaration de conflit d'intérêts
Conflicts of Interest: The authors have no conflicts of interest to declare.
Références
Oncotarget. 2017 Sep 1;8(43):73433-73447
pubmed: 29088718
Hepatology. 2010 May;51(5):1603-13
pubmed: 20432254
Nat Rev Immunol. 2017 Feb;17(2):97-111
pubmed: 27748397
Hum Gene Ther. 2009 Nov;20(11):1229-39
pubmed: 19702437
Semin Diagn Pathol. 2017 Mar;34(2):192-200
pubmed: 28126357
Cell Metab. 2019 May 7;29(5):1135-1150.e6
pubmed: 30713111
Nature. 2004 Oct 28;431(7012):1112-7
pubmed: 15475948
J Exp Med. 2005 Dec 19;202(12):1691-701
pubmed: 16365148
Oncotarget. 2019 Feb 19;10(15):1475-1490
pubmed: 30863496
Hepatology. 2018 Jul;68(1):89-102
pubmed: 29152775
Asian Pac J Cancer Prev. 2015;16(3):1029-31
pubmed: 25735325
Annu Rev Pathol. 2018 Jan 24;13:351-378
pubmed: 29125798
Oncoimmunology. 2013 Jan 1;2(1):e22620
pubmed: 23482411
Genes Chromosomes Cancer. 2016 Dec;55(12):925-931
pubmed: 27356182
J Clin Oncol. 2005 Feb 20;23(6):1245-52
pubmed: 15718322
Eur J Cancer. 2000 Jul;36(11):1418-25
pubmed: 10899656
Gastroenterology. 2015 Jun;148(7):1294-310
pubmed: 25747274
JCI Insight. 2016 Oct 06;1(16):e88549
pubmed: 27734029
Am J Pathol. 2019 May;189(5):1077-1090
pubmed: 30794805
Cancer Res. 2002 Apr 1;62(7):1971-7
pubmed: 11929813
Gastroenterology. 2014 Sep;147(3):690-701
pubmed: 24837480
Hepatology. 2016 Nov;64(5):1587-1605
pubmed: 27097116
Hepatology. 2009 Feb;49(2):482-90
pubmed: 19177589
Nat Rev Cancer. 2005 Jun;5(6):481-8
pubmed: 15905853
Cancer Cell. 2008 Dec 9;14(6):471-84
pubmed: 19061838
Cancer Res. 1999 Jan 15;59(2):269-73
pubmed: 9927029
Cancer Res. 2004 Jan 1;64(1):48-54
pubmed: 14729607
Hepatology. 2014 Nov;60(5):1686-96
pubmed: 24912477
Oncoimmunology. 2019 Mar 28;8(6):e1583547
pubmed: 31069152
Hepatology. 2017 May;65(5):1581-1599
pubmed: 27981621
Growth Factors. 2011 Dec;29(6):221-34
pubmed: 21875383
Lancet Oncol. 2017 Jan;18(1):122-131
pubmed: 27884679
Cancers (Basel). 2019 Mar 22;11(3):
pubmed: 30909445
Hum Pathol. 2009 Jun;40(6):783-94
pubmed: 19200579
J Clin Oncol. 2017 Jan;35(1):115-116
pubmed: 28034077
Front Oncol. 2019 Apr 10;9:248
pubmed: 31024850
Cancer Treat Rev. 2018 Jan;62:50-60
pubmed: 29169144
Lancet Oncol. 2013 Aug;14(9):834-42
pubmed: 23831416
Int J Oncol. 2019 May;54(5):1853-1863
pubmed: 30864675
EMBO J. 2012 Jun 13;31(12):2670-84
pubmed: 22617420
Nat Rev Clin Oncol. 2015 Aug;12(8):445-64
pubmed: 25850553
Cancer Cell. 2014 Aug 11;26(2):248-61
pubmed: 25117712
J Gastrointest Oncol. 2018 Apr;9(2):326-337
pubmed: 29755772
Int J Mol Med. 2017 Sep;40(3):587-606
pubmed: 28731148
Lancet Oncol. 2019 May;20(5):719-727
pubmed: 30975630
Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17216-21
pubmed: 15563600
Hepatology. 2017 Jan;65(1):104-121
pubmed: 27775819