Tumor dormancy in bone.
angiogenesis
bone marrow
dormancy
hypoxia
immune surveillance
metastasis
Journal
Cancer reports (Hoboken, N.J.)
ISSN: 2573-8348
Titre abrégé: Cancer Rep (Hoboken)
Pays: United States
ID NLM: 101747728
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
entrez:
8
7
2020
pubmed:
8
7
2020
medline:
30
11
2021
Statut:
ppublish
Résumé
Bone marrow is a common site of metastasis for a number of tumor types, including breast, prostate, and lung cancer, but the mechanisms controlling tumor dormancy in bone are poorly understood. In breast cancer, while advances in drug development, screening practices, and surgical techniques have dramatically improved survival rates in recent decades, metastatic recurrence in the bone remains common and can develop years or decades after elimination of the primary tumor. It is now understood that tumor cells disseminate to distant metastatic sites at early stages of tumor progression, leaving cancer survivors at a high risk of recurrence. This review will discuss mechanisms of bone lesion development and current theories of how dormant cancer cells behave in bone, as well as a number of processes suspected to be involved in the maintenance of and exit from dormancy in the bone microenvironment. The bone is a complex microenvironment with a multitude of cell types and processes. Many of these factors, including angiogenesis, immune surveillance, and hypoxia, are thought to regulate tumor cell entry and exit from dormancy in different bone marrow niches.
Sections du résumé
Background
Bone marrow is a common site of metastasis for a number of tumor types, including breast, prostate, and lung cancer, but the mechanisms controlling tumor dormancy in bone are poorly understood. In breast cancer, while advances in drug development, screening practices, and surgical techniques have dramatically improved survival rates in recent decades, metastatic recurrence in the bone remains common and can develop years or decades after elimination of the primary tumor.
Recent Findings
It is now understood that tumor cells disseminate to distant metastatic sites at early stages of tumor progression, leaving cancer survivors at a high risk of recurrence. This review will discuss mechanisms of bone lesion development and current theories of how dormant cancer cells behave in bone, as well as a number of processes suspected to be involved in the maintenance of and exit from dormancy in the bone microenvironment.
Conclusions
The bone is a complex microenvironment with a multitude of cell types and processes. Many of these factors, including angiogenesis, immune surveillance, and hypoxia, are thought to regulate tumor cell entry and exit from dormancy in different bone marrow niches.
Identifiants
pubmed: 32632400
doi: 10.1002/cnr2.1156
pmc: PMC7337256
mid: NIHMS1570248
doi:
Substances chimiques
CXCR4 protein, human
0
Receptors, CXCR4
0
Protein-Lysine 6-Oxidase
EC 1.4.3.13
Ribosomal Protein S6 Kinases, 90-kDa
EC 2.7.11.1
mitogen and stress-activated protein kinase 1
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1156Subventions
Organisme : NCI NIH HHS
ID : R00 CA194198
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM008554
Pays : United States
Déclaration de conflit d'intérêts
CONFLICT OF INTEREST The authors have no conflicts of interest to declare.
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