Separation and thickness measurements of superficial and deep slabs of the retinal nerve fiber layer in healthy and glaucomatous eyes.
Journal
Ophthalmology. Glaucoma
ISSN: 2589-4196
Titre abrégé: Ophthalmol Glaucoma
Pays: United States
ID NLM: 101730510
Informations de publication
Date de publication:
Historique:
entrez:
8
7
2020
pubmed:
8
7
2020
medline:
7
9
2021
Statut:
ppublish
Résumé
Describe a new method to analyze retinal nerve fiber layer (RNFL) thickness maps. Cross-sectional study. RNFL thickness maps of healthy and glaucomatous eyes. Optical coherence tomography (OCT) RNFL raster scans from 98 healthy and 50 glaucomatous eyes were analyzed. The RNFL thickness maps were separated into superficial (SNFL) and deep (DNFL) slabs through a partial thickness plane set at the modal thickness (mode). Association between mode and OCT signal strength (SS), age, axial length, and visual field mean deviation (VFMD) was tested (Pearson coefficient, Thickness of regions in SNFL and DNFL slabs. The mode was not associated with SS, age, axial length, or VFMD, it circumscribed the thicker RNFL around the optic disc of healthy and glaucomatous eyes, and it was used to separate the SNFL and DNFL slabs of RNFL thickness maps. The thickness of the SNFL slab was less in glaucomatous eyes than in healthy eyes ( Glaucomatous RNFL thinning is predominantly detected within a slab with thickness greater than the mode. SNFL thickness has great AUC and correlation with VFMD in glaucomatous eyes. The usefulness for diagnosis and monitoring of glaucoma needs further study.
Identifiants
pubmed: 32632406
doi: 10.1016/j.ogla.2019.11.004
pmc: PMC7337289
mid: NIHMS1545479
doi:
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
66-75Subventions
Organisme : NEI NIH HHS
ID : P30 EY014801
Pays : United States
Déclaration de conflit d'intérêts
Conflict of Interest No conflicting relationship exists for any author
Références
J Glaucoma. 2008 Oct-Nov;17(7):519-28
pubmed: 18854727
J Glaucoma. 2009 Mar;18(3):213-6
pubmed: 19295375
Arch Ophthalmol. 1995 May;113(5):586-96
pubmed: 7748128
Br J Ophthalmol. 2012 Jan;96(1):57-61
pubmed: 21349942
Artif Intell Med. 2015 Jun;64(2):105-15
pubmed: 25940856
J Glaucoma. 2016 Feb;25(2):208-16
pubmed: 25264997
Invest Ophthalmol Vis Sci. 1983 Jan;24(1):85-98
pubmed: 6826318
Br J Ophthalmol. 2005 Apr;89(4):489-92
pubmed: 15774930
Am J Ophthalmol. 2012 May;153(5):815-826.e2
pubmed: 22265147
J Glaucoma. 2012 Apr-May;21(4):260-5
pubmed: 21623226
J Glaucoma. 2009 Sep;18(7):501-5
pubmed: 19745664
Ophthalmology. 2008 Aug;115(8):1347-51, 1351.e1-2
pubmed: 18294689
Invest Ophthalmol Vis Sci. 2013 Nov 08;54(12):7338-43
pubmed: 24135758
Am J Ophthalmol. 2015 Mar;159(3):545-56.e2
pubmed: 25498354
Ophthalmology. 2009 Jul;116(7):1271-7
pubmed: 19395086
Ophthalmology. 2012 Jun;119(6):1151-8
pubmed: 22365056
J Neuroophthalmol. 2016 Dec;36(4):417-438
pubmed: 27636747
Prog Retin Eye Res. 2017 Mar;57:46-75
pubmed: 28012881
Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5724-30
pubmed: 20574014
Invest Ophthalmol Vis Sci. 2014 Feb 20;55(2):1048-55
pubmed: 24458157
Prog Retin Eye Res. 2013 Jan;32:1-21
pubmed: 22995953
J Glaucoma. 2011 Mar;20(3):133-8
pubmed: 20577113
Arch Ophthalmol. 2012 Mar;130(3):312-8
pubmed: 22411660
Ophthalmology. 2011 Feb;118(2):241-8.e1
pubmed: 20920824
Invest Ophthalmol Vis Sci. 2013 Dec 11;54(13):8095-103
pubmed: 24194190
Ophthalmology. 2007 Jun;114(6):1046-52
pubmed: 17210181
Invest Ophthalmol Vis Sci. 2014 Jul 29;55(8):5116-24
pubmed: 25074779
Curr Opin Ophthalmol. 2012 Mar;23(2):79-88
pubmed: 22262083
J Comp Neurol. 1990 Oct 1;300(1):5-25
pubmed: 2229487