Incidence and clinical profiles of COVID-19 pneumonia in pregnant women: A single-centre cohort study from Spain.
ALT, alanine aminotransferase
ARDS, acute respiratory distress syndrome
AST, aspartate aminotransferase
COVID-19
COVID-19, coronavirus disease 2019
CRP, C-reactive protein
CT, computerized tomography
Coronavirus
HCQ, hydroxychloroquine
ICU, intensive care unit
IFN-β, interferon-β
IMV, invasive mechanical ventilation
IQR, interquartile range
IV, intravenous
LPV/r, lopinavir/ritonavir
Pneumonia
Pregnancy
RT-PCR, reverse transcription polymerase chain reaction
Risk stratification
SARS-CoV-2
SARS-CoV-2, severe acute respiratory syndrome coronavirus 2
TCZ, tocilizumab
URTI, upper respiratory tract infection
ePaO2/FiO2, estimated arterial oxygen/fraction of inspired oxygen ratio
Journal
EClinicalMedicine
ISSN: 2589-5370
Titre abrégé: EClinicalMedicine
Pays: England
ID NLM: 101733727
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
09
05
2020
revised:
19
05
2020
accepted:
21
05
2020
entrez:
8
7
2020
pubmed:
8
7
2020
medline:
8
7
2020
Statut:
epublish
Résumé
Information regarding the incidence and characteristics of COVID-19 pneumonia amongst pregnant women is scarce. Single-centre experience with 32 pregnant women diagnosed with COVID-19 between March 5 to April 5, 2020 at Madrid, Spain. COVID-19 pneumonia was diagnosed in 61·5% (32/52) women. Only 18·7% (6/32) had some underlying condition (mostly asthma). Supplemental oxygen therapy was required in 18 patients (56·3%), with high-flow requirements in six (18·7%). Eight patients (25·0%) fulfilled the criteria for acute distress respiratory syndrome. Invasive mechanical ventilation was required in two patients (6·2%). Tocilizumab was administered in five patients (15·6%). Delivery was precipitated due to COVID-19 in three women (9·4%). All the newborns had a favourable outcome, with no cases of neonatal SARS-CoV-2 transmission. Severe cases of pneumonia requiring supplemental oxygen were more likely to exhibit bilateral alveolar or interstitial infiltrates on chest X-ray (55·6% vs. 0·0%; Pregnant women with COVID-19 have a high risk of developing pneumonia, with a severe course in more than half of cases. The presence of bilateral kung infiltrates and elevated serum CRP at admission may identify women at-risk of severe COVID-19 pneumonia. Instituto de Salud Carlos III (COV20/00,181), Spanish Ministry of Science and Innovation.
Sections du résumé
BACKGROUND
BACKGROUND
Information regarding the incidence and characteristics of COVID-19 pneumonia amongst pregnant women is scarce.
METHODS
METHODS
Single-centre experience with 32 pregnant women diagnosed with COVID-19 between March 5 to April 5, 2020 at Madrid, Spain.
FINDINGS
RESULTS
COVID-19 pneumonia was diagnosed in 61·5% (32/52) women. Only 18·7% (6/32) had some underlying condition (mostly asthma). Supplemental oxygen therapy was required in 18 patients (56·3%), with high-flow requirements in six (18·7%). Eight patients (25·0%) fulfilled the criteria for acute distress respiratory syndrome. Invasive mechanical ventilation was required in two patients (6·2%). Tocilizumab was administered in five patients (15·6%). Delivery was precipitated due to COVID-19 in three women (9·4%). All the newborns had a favourable outcome, with no cases of neonatal SARS-CoV-2 transmission. Severe cases of pneumonia requiring supplemental oxygen were more likely to exhibit bilateral alveolar or interstitial infiltrates on chest X-ray (55·6% vs. 0·0%;
INTERPRETATION
CONCLUSIONS
Pregnant women with COVID-19 have a high risk of developing pneumonia, with a severe course in more than half of cases. The presence of bilateral kung infiltrates and elevated serum CRP at admission may identify women at-risk of severe COVID-19 pneumonia.
FUNDING
BACKGROUND
Instituto de Salud Carlos III (COV20/00,181), Spanish Ministry of Science and Innovation.
Identifiants
pubmed: 32632417
doi: 10.1016/j.eclinm.2020.100407
pii: S2589-5370(20)30151-6
pii: 100407
pmc: PMC7295514
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100407Informations de copyright
© 2020 The Author(s).
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