Crystal Structures, Stability, and Solubility Evaluation of a 2:1 Diosgenin-Piperazine Cocrystal.
Characterization
Cocrystal
Diosgenin
Piperazine
Solubility
Journal
Natural products and bioprospecting
ISSN: 2192-2195
Titre abrégé: Nat Prod Bioprospect
Pays: Germany
ID NLM: 101577734
Informations de publication
Date de publication:
Aug 2020
Aug 2020
Historique:
received:
25
04
2020
accepted:
17
06
2020
pubmed:
8
7
2020
medline:
8
7
2020
entrez:
8
7
2020
Statut:
ppublish
Résumé
A cocrystal of diosgenin with piperazine in 2:1 stoichiometry was successfully synthesized. The solid form was prepared by liquid assisted grinding, slurry and crystallization methods. The cocrystal was characterized by powder X-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, Fourier transform infrared spectroscopy, and structure determined by single crystal X-ray diffraction, the hydrogen bonds formed into fish bone structure along the [010] direction and all the molecules packed into 3D layer structure along a axis. After formation of cocrystal, the solubility of diosgenin was improved, and the solubility value in 0.2% SDS solution was approximately 1.5 times as large as that of the parent material.
Identifiants
pubmed: 32632767
doi: 10.1007/s13659-020-00256-y
pii: 10.1007/s13659-020-00256-y
pmc: PMC7367958
doi:
Types de publication
Journal Article
Langues
eng
Pagination
261-267Subventions
Organisme : National Key research and development Program of China
ID : 2016YFC1000900
Organisme : CAMS Innovation Found for Medical Sciences
ID : 2017-I2M-1-010
Organisme : Construction and application of technology integration system for efficient identification of natural/effective active small molecules
ID : 2018ZX09711001-001
Organisme : National Science and Technology Major Project of China
ID : 2018ZX09711001-010
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