Control the fate of human umbilical cord mesenchymal stem cells with dual-enzymatically cross-linked gelatin hydrogels for potential applications in nerve regeneration.
Animals
Biocompatible Materials
/ pharmacology
Cell Death
/ drug effects
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Cross-Linking Reagents
/ pharmacology
Elastic Modulus
Gelatin
/ chemical synthesis
Hemolysis
/ drug effects
Humans
Hydrogels
/ pharmacology
Hydrogen Peroxide
/ chemistry
Mesenchymal Stem Cells
/ cytology
Mice, Inbred C57BL
Nerve Regeneration
/ drug effects
Nerve Tissue Proteins
/ metabolism
Neurons
/ cytology
Swine
Time Factors
Umbilical Cord
/ cytology
Water
/ chemistry
dual-enzymatically cross-linked gelatin hydrogels
human umbilical cord mesenchymal stem cells
neural differentiation
three-dimensional culture
Journal
Journal of tissue engineering and regenerative medicine
ISSN: 1932-7005
Titre abrégé: J Tissue Eng Regen Med
Pays: England
ID NLM: 101308490
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
15
04
2020
revised:
29
06
2020
accepted:
01
07
2020
pubmed:
8
7
2020
medline:
30
9
2021
entrez:
8
7
2020
Statut:
ppublish
Résumé
Stem-cell-based therapy is a promising strategy to treat challenging neurological diseases, while its application is hindered primarily by the low viability and uncontrolled differentiation of stem cell. Hydrogel can be properly engineered to share similar characteristics with the target tissue, thus promoting cell viability and directing cell differentiation. In this study, we proposed a new dual-enzymatically cross-linked and injectable gelatin hydrogel for regulating survival, proliferation, and differentiation of human umbilical cord mesenchymal stem cells (hUC-MSCs) in a three-dimensional matrix. This injectable gelatin hydrogel was formed by oxidative coupling of gelatin-hydroxyphenyl acid conjugates catalyzed by hydrogen horseradish peroxidase (HRP) and choline oxidase (ChOx). Modulus and H
Substances chimiques
Biocompatible Materials
0
Cross-Linking Reagents
0
Hydrogels
0
Nerve Tissue Proteins
0
Water
059QF0KO0R
Gelatin
9000-70-8
Hydrogen Peroxide
BBX060AN9V
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1261-1271Informations de copyright
© 2020 John Wiley & Sons, Ltd.
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