Distinct roles for major and minor antigen barriers in chimerism-based tolerance under irradiation-free conditions.
basic (laboratory) research/science
immunobiology
tolerance: chimerism
tolerance: costimulation blockade
tolerance: experimental
tolerance: mechanisms
Journal
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638
Informations de publication
Date de publication:
03 2021
03 2021
Historique:
received:
14
04
2020
revised:
10
06
2020
accepted:
19
06
2020
pubmed:
8
7
2020
medline:
22
6
2021
entrez:
8
7
2020
Statut:
ppublish
Résumé
Eliminating cytoreductive conditioning from chimerism-based tolerance protocols would facilitate clinical translation. Here we investigated the impact of major histocompatibility complex (MHC) and minor histocompatibility antigen (MiHA) barriers on mechanisms of tolerance and rejection in this setting. Transient depletion of natural killer (NK) cells at the time of bone marrow (BM) transplantation (BMT) (20 × 10
Identifiants
pubmed: 32633070
doi: 10.1111/ajt.16177
pmc: PMC7984377
pii: S1600-6135(22)08434-9
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
968-977Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2020 The Authors. American Journal of Transplantation published by Wiley Periodicals LLC on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons.
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