Dysregulation of CCN3 (NOV) expression in the epidermis of systemic sclerosis patients with pigmentary changes.
CCN3
NOV
epidermis
keratinocytes
melanocytes
scleroderma
systemic sclerosis
Journal
Pigment cell & melanoma research
ISSN: 1755-148X
Titre abrégé: Pigment Cell Melanoma Res
Pays: England
ID NLM: 101318927
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
31
03
2020
revised:
04
06
2020
accepted:
30
06
2020
pubmed:
8
7
2020
medline:
13
8
2021
entrez:
8
7
2020
Statut:
ppublish
Résumé
Systemic sclerosis (SSc) is a severe disease whose pathophysiology remains partly unknown, combining autoimmune, vascular, and fibrotic features. Recently, we evidenced a link between vasculopathy and pigmentary changes in SSc. CCN3 (NOV) is a matricellular protein implicated in both angiogenesis and pigmentation regulation, in particular melanocyte adhesion to the basal layer. We decided to study CCN3 expression in SSc epidermis. We show that in SSc patients with pigmentary changes compared to patients with normal pigmentation, CCN3 is specifically downregulated in situ in melanocytes and upregulated in keratinocytes. Moreover, the number of melanocytes is significantly decreased in SSc patients with a disease duration of more than 5 years compared to the other patients. Altogether, our findings could provide new insights on the mechanisms of pigmentary changes in SSc patients, as well as treatment adaptation in a personalized manner.
Substances chimiques
CCN3 protein, human
0
Nephroblastoma Overexpressed Protein
0
Types de publication
Letter
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
895-898Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.