Examining Uncertainty in In Vitro-In Vivo Extrapolation Applied in Fish Bioconcentration Models.

Animals Bioaccumulation Biotransformation Liver / metabolism Models, Biological Oncorhynchus mykiss Uncertainty Water Pollutants, Chemical / metabolism

Journal

Environmental science & technology
ISSN: 1520-5851
Titre abrégé: Environ Sci Technol
Pays: United States
ID NLM: 0213155

Informations de publication

Date de publication:
04 08 2020
Historique:
pubmed: 8 7 2020
medline: 28 11 2020
entrez: 8 7 2020
Statut: ppublish

Résumé

In vitro biotransformation rates were determined for 30 chemicals, mostly fragrance ingredients, using trout liver S9 fractions (RT-S9) and incorporated into in vitro-in vivo extrapolation (IVIVE) models to predict bioconcentration factors (BCFs). Predicted BCFs were compared against empirical BCFs to explore potential major uncertainties involved in the in vitro methods and IVIVE models: (i) in vitro chemical test concentrations; (ii) different gill uptake rate constant calculations (

Identifiants

DOI: 10.1021/acs.est.0c01492 PMID: 32633948
pubmed: 32633948
doi: 10.1021/acs.est.0c01492
doi:

Substances chimiques

Water Pollutants, Chemical 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

9483-9494

Auteurs

Heike Laue (H)

Givaudan Schweiz AG, Fragrances S&T, 8310 Kemptthal, Switzerland.
ORCID: 0000-0001-8923-7802

Lu Hostettler (L)

Givaudan Schweiz AG, Fragrances S&T, 8310 Kemptthal, Switzerland.

Remo P Badertscher (RP)

Givaudan Schweiz AG, Fragrances S&T, 8310 Kemptthal, Switzerland.

Karen J Jenner (KJ)

Givaudan UK Ltd, Regulatory Affairs and Product Safety, Ashford, Kent TN24 OLT, United Kingdom.

Gordon Sanders (G)

Givaudan International SA, Regulatory Affairs and Product Safety, 1214 Vernier, Switzerland.

Jon A Arnot (JA)

ARC Arnot Research and Consulting, Toronto, Ontario M4M 1W4, Canada.

Andreas Natsch (A)

Givaudan Schweiz AG, Fragrances S&T, 8310 Kemptthal, Switzerland.
ORCID: 0000-0003-2231-2489

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Examining Uncertainty in In Vitro-In Vivo...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Absorption › Absorption physiologique › Bioaccumulation › Examining Uncertainty in In Vitro-In Vivo...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Biotransformation › Examining Uncertainty in In Vitro-In Vivo...
questionsmedicales.fr › Système digestif › Foie › Examining Uncertainty in In Vitro-In Vivo...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Examining Uncertainty in In Vitro-In Vivo...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Salmoniformes › Salmonidae › Truite › Oncorhynchus › Oncorhynchus mykiss › Examining Uncertainty in In Vitro-In Vivo...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Incertitude › Examining Uncertainty in In Vitro-In Vivo...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Polluants de l'eau › Polluants chimiques de l'eau › Examining Uncertainty in In Vitro-In Vivo...