Mitochondrial Respiratory Capacity is Restored in Hibernating Cardiomyocytes Following Co-Culture with Mesenchymal Stem Cells.
Hibernating myocardium
mesenchymal stem cells
mitochondrial respiration
peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Journal
Cell medicine
ISSN: 2155-1790
Titre abrégé: Cell Med
Pays: United States
ID NLM: 101544564
Informations de publication
Date de publication:
2019
2019
Historique:
received:
16
11
2018
revised:
22
01
2019
accepted:
11
02
2019
entrez:
8
7
2020
pubmed:
6
3
2019
medline:
6
3
2019
Statut:
epublish
Résumé
Hibernating myocardium is a subset of ischemic cardiac disease characterized by viable but dysfunctional tissue. Standard treatment for hibernating myocardium is coronary artery bypass graft, which reduces arrhythmias and improves survival but does not fully restore function, presenting a gap in currently available treatments. Large animal studies of hibernating myocardium have identified impaired mitochondrial dynamics as a root cause of persistent cardiac dysfunction despite surgical revascularization. This study presents a novel
Identifiants
pubmed: 32634193
doi: 10.1177/2155179019834938
pii: 10.1177_2155179019834938
pmc: PMC6404044
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2155179019834938Subventions
Organisme : BLRD VA
ID : I01 BX000760
Pays : United States
Informations de copyright
© The Author(s) 2019.
Déclaration de conflit d'intérêts
Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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