A comparison of mortality-related risk factors of COVID-19, SARS, and MERS: A systematic review and meta-analysis.
Betacoronavirus
C-Reactive Protein
/ analysis
COVID-19
Coronavirus Infections
/ epidemiology
Diabetes Mellitus
/ pathology
Female
Humans
Hypertension
/ pathology
L-Lactate Dehydrogenase
/ blood
Lung Diseases
/ pathology
Male
Middle East Respiratory Syndrome Coronavirus
Neutrophils
/ cytology
Pandemics
Pneumonia, Viral
/ epidemiology
Risk Factors
Severe acute respiratory syndrome-related coronavirus
SARS-CoV-2
Severe Acute Respiratory Syndrome
/ epidemiology
Sex Factors
COVID-19
MERS
Meta-analysis
Mortality
Risk factors
SARS
Journal
The Journal of infection
ISSN: 1532-2742
Titre abrégé: J Infect
Pays: England
ID NLM: 7908424
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
30
04
2020
accepted:
01
07
2020
pubmed:
8
7
2020
medline:
6
10
2020
entrez:
8
7
2020
Statut:
ppublish
Résumé
Coronavirus Disease 2019 (COVID-19) is a pandemic. This systematic review compares mortality risk factors including clinical, demographic and laboratory features of COVID-19, Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). The aim is to provide new strategies for COVID-19 prevention and treatment. We performed a systematic review with meta-analysis, using five databases to compare the predictors of death for COVID-19, SARS and MERS. A random-effects model meta-analysis calculated odds ratios (OR) and 95% confidence intervals (95% CI). 845 articles up through 11/4/2020 were retrieved, but only 28 studies were included in this meta-analysis. The results showed that males had a higher likelihood of death than females (OR = 1.82, 95% CI 1.56-2.13). Age (OR = 7.86, 95% CI 5.46-11.29), diabetes comorbidity (OR = 3.73, 95% CI 2.35-5.90), chronic lung disease (OR = 3.43, 95% CI 1.80-6.52) and hypertension (OR = 3.38, 95% CI 2.45-4.67) were the mortality risk factors. The laboratory indicators lactic dehydrogenase (OR = 37.52, 95% CI 24.68-57.03), C-reactive protein (OR = 12.11, 95% CI 5.24-27.98), and neutrophils (OR = 17.56, 95% CI 10.67-28.90) had stronger correlations with COVID-19 mortality than with SARS or MERS mortality. Consolidation and ground-glass opacity imaging features were similar among COVID-19, SARS, and MERS patients. COVID-19's mortality factors are similar to those of SARS and MERS. Age and laboratory indicators could be effective predictors of COVID-19 mortality outcomes.
Identifiants
pubmed: 32634459
pii: S0163-4453(20)30460-6
doi: 10.1016/j.jinf.2020.07.002
pmc: PMC7334925
pii:
doi:
Substances chimiques
C-Reactive Protein
9007-41-4
L-Lactate Dehydrogenase
EC 1.1.1.27
Types de publication
Comparative Study
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e18-e25Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare having no conflict of interest related to this work.
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