Effect of fomesafen on the embryonic development of zebrafish.

Animals Apoptosis / drug effects Benzamides / toxicity Embryo, Nonmammalian / drug effects Embryonic Development / drug effects Herbicides / toxicity Oxidative Stress / drug effects Up-Regulation Zebrafish / embryology
Cell apoptosis Developmental toxicity Fomesafen Oxidative stress Zebrafish

Journal

Chemosphere
ISSN: 1879-1298
Titre abrégé: Chemosphere
Pays: England
ID NLM: 0320657

Informations de publication

Date de publication:
Nov 2020
Historique:
received: 03 05 2020
revised: 06 06 2020
accepted: 08 06 2020
pubmed: 8 7 2020
medline: 18 9 2020
entrez: 8 7 2020
Statut: ppublish

Résumé

Fomesafen is widely used in agriculture and can be detected in the environment and agricultural products. Research on the developmental toxicity of fomesafen in animals is currently very limited. Here, we used zebrafish as an animal model to evaluate the toxicity of fomesafen in developing aquatic vertebrates and higher animals. From 6h to 72h following fertilization, exposure of zebrafish embryos to 5, 10 and 20 mg/L of fomesafen resulted in pericardial edema, a reduction in heart rate, shortening of body length, and yolk sac edema. Fomesafen reduced the number of immune cells such as neutrophils and macrophages, increased the expression of a number of inflammatory factors, induced the up-regulation of the oxidative stress response and apoptosis, and disrupted the activity of enzymes related to nerve development, which affected the motility of the embryos. In conclusion, the results provide new evidence for the comprehensive assessment of fomesafen toxicity in aquatic vertebrates.

Identifiants

DOI: 10.1016/j.chemosphere.2020.127380 PMID: 32634720
pubmed: 32634720
pii: S0045-6535(20)31573-3
doi: 10.1016/j.chemosphere.2020.127380
pii:
doi:

Substances chimiques

Benzamides 0
Herbicides 0
fomesafen M0A3U4CDTF

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

127380

Informations de copyright

Copyright © 2020. Published by Elsevier Ltd.

Déclaration de conflit d'intérêts

Declaration of competing interest The author reports no conflicts of interest in this work.

Auteurs

Zhaopeng Xu (Z)

Center for drug screening and research, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou, 341000, Jiangxi, China; College of life and science, Gannan Normal University, Ganzhou, 341000, Jiangxi, China.

Huiwen Ni (H)

Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Ji'an, 343009, Jiangxi, China; Jiangxi Key Laboratory of Developmental Biology of Organs, Jinggangshan University, Ji'an, 343009, Jiangxi, China.

Yong Huang (Y)

Center for drug screening and research, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou, 341000, Jiangxi, China.

Yunlong Meng (Y)

Center for drug screening and research, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou, 341000, Jiangxi, China.

Zigang Cao (Z)

Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Ji'an, 343009, Jiangxi, China; Jiangxi Key Laboratory of Developmental Biology of Organs, Jinggangshan University, Ji'an, 343009, Jiangxi, China.

Xinjun Liao (X)

Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Ji'an, 343009, Jiangxi, China; Jiangxi Key Laboratory of Developmental Biology of Organs, Jinggangshan University, Ji'an, 343009, Jiangxi, China.

Shouhua Zhang (S)

Department of General Surgery, Jiangxi Provincial Children's Hospital, Nanchang, 330006, China.

Xinchun Guo (X)

Center for drug screening and research, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou, 341000, Jiangxi, China; College of life and science, Gannan Normal University, Ganzhou, 341000, Jiangxi, China. Electronic address: guoxinchun01@163.com.

Huiqiang Lu (H)

Center for drug screening and research, School of Geography and Environmental Engineering, Gannan Normal University, Ganzhou, 341000, Jiangxi, China; College of life and science, Gannan Normal University, Ganzhou, 341000, Jiangxi, China; Jiangxi Engineering Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases, Ji'an, 343009, Jiangxi, China; Jiangxi Key Laboratory of Developmental Biology of Organs, Jinggangshan University, Ji'an, 343009, Jiangxi, China. Electronic address: luhq2@126.com.

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Effect of fomesafen on the embryonic...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Effect of fomesafen on the embryonic...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Benzoates › Benzamides › Effect of fomesafen on the embryonic...
questionsmedicales.fr › Structures de l'embryon › Embryon non mammalien › Effect of fomesafen on the embryonic...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Effect of fomesafen on the embryonic...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Pesticides › Herbicides › Effect of fomesafen on the embryonic...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Effect of fomesafen on the embryonic...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Régulation positive › Effect of fomesafen on the embryonic...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › Effect of fomesafen on the embryonic...