Ameliorative Effects of Rhoifolin in Scopolamine-Induced Amnesic Zebrafish (
anxiety
cholinergic function
memory
oxidative stress
rhoifolin
zebrafish
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
03 Jul 2020
03 Jul 2020
Historique:
received:
27
05
2020
revised:
23
06
2020
accepted:
25
06
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
9
7
2020
Statut:
epublish
Résumé
Rhoifolin (Rho) exerts many biological activities such as anticancer, antidiabetic, hepatoprotective, antirheumatic, antibacterial, and antiviral properties. The neuroprotective action of this compound has not been studied. The goal of this study was to investigate the improvement impact of Rho on scopolamine (Sco)-induced zebrafish anxiety, amnesia, and brain oxidative stress and to elucidate the underlying mechanisms involved. Zebrafish were treated with Rho (1, 3, and 5 μg/L) for nine consecutive days and were subsequently subjected to Sco (100 μM) 30 min before behavioral tests (novel tank diving test, Y-maze, and novel object recognition tests). Rho was isolated from
Identifiants
pubmed: 32635149
pii: antiox9070580
doi: 10.3390/antiox9070580
pmc: PMC7401873
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : This project is funded by the Ministry of Research and Innovation within Program 1 - Development of the national RD system, Subprogram 1.2 - Institutional Performance - RDI excellence funding projects
ID : Contract no. 34PFE/19.10.2018
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