Elective Neck Dissection or Sentinel Lymph Node Biopsy in Early Stage Oral Cavity Cancer Patients: The Dutch Experience.
elective neck dissection
lymph node metastases
lymphatics
oral cancer
sentinel lymph node biopsy
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
03 Jul 2020
03 Jul 2020
Historique:
received:
24
05
2020
revised:
28
06
2020
accepted:
30
06
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
9
7
2020
Statut:
epublish
Résumé
Sentinel lymph node biopsy (SLNB) has been introduced as a diagnostic staging modality for detection of occult metastases in patients with early stage oral cancer. Comparisons regarding accuracy to the routinely used elective neck dissection (END) are lacking in literature. A retrospective, multicenter cohort study included 390 patients staged by END and 488 by SLNB. The overall sensitivity (84% vs. 81%, In the absence of randomized clinical trials, this study provides the highest available evidence that, in oral cancer, SLNB is as accurate as END in detecting occult lymph node metastases, except for floor-of-mouth tumours.
Sections du résumé
BACKGROUND
BACKGROUND
Sentinel lymph node biopsy (SLNB) has been introduced as a diagnostic staging modality for detection of occult metastases in patients with early stage oral cancer. Comparisons regarding accuracy to the routinely used elective neck dissection (END) are lacking in literature.
METHODS
METHODS
A retrospective, multicenter cohort study included 390 patients staged by END and 488 by SLNB.
RESULTS
RESULTS
The overall sensitivity (84% vs. 81%,
CONCLUSION
CONCLUSIONS
In the absence of randomized clinical trials, this study provides the highest available evidence that, in oral cancer, SLNB is as accurate as END in detecting occult lymph node metastases, except for floor-of-mouth tumours.
Identifiants
pubmed: 32635357
pii: cancers12071783
doi: 10.3390/cancers12071783
pmc: PMC7407164
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Ann Surg Oncol. 2015 Oct;22(11):3708-15
pubmed: 25670018
Eur J Nucl Med Mol Imaging. 2012 Jul;39(7):1128-36
pubmed: 22526966
Head Neck. 2015 Dec;37(12):1829-39
pubmed: 24954811
Ann Surg Oncol. 2016 Feb;23(2):565-72
pubmed: 26467454
Head Neck. 2016 Sep;38(9):1367-72
pubmed: 27027415
Ann Surg Oncol. 2009 Nov;16(11):3190-210
pubmed: 19795174
Oral Oncol. 2014 Oct;50(10):1020-4
pubmed: 25164950
Laryngoscope. 2019 Jan;129(1):162-169
pubmed: 30284248
Head Neck. 2011 Sep;33(9):1260-4
pubmed: 21837694
Ann Surg Oncol. 2010 Sep;17(9):2459-64
pubmed: 20552410
PLoS One. 2017 Jan 20;12(1):e0170322
pubmed: 28107500
Cancer. 1990 Jul 1;66(1):109-13
pubmed: 2354399
J Craniomaxillofac Surg. 2016 May;44(5):550-6
pubmed: 26948173
Br J Oral Maxillofac Surg. 2017 Oct;55(8):757-762
pubmed: 28864148
Head Neck. 2009 Apr;31(4):503-12
pubmed: 19156833
Head Neck. 2019 Aug;41(8):2655-2664
pubmed: 30896058
CA Cancer J Clin. 2017 Mar;67(2):122-137
pubmed: 28128848
Head Neck. 2005 Dec;27(12):1080-91
pubmed: 16240329
Oral Oncol. 2015 Sep;51(9):819-23
pubmed: 26126813
Int J Oral Maxillofac Surg. 2014 Nov;43(11):1307-12
pubmed: 25128262
Oral Oncol. 2012 Apr;48(4):337-42
pubmed: 22130455
Cancer. 1999 Dec 15;86(12):2668-73
pubmed: 10594862
Head Neck. 2016 Apr;38 Suppl 1:E1033-40
pubmed: 26040238
Head Neck. 2019 Jul;41(7):2100-2106
pubmed: 30688384
J Oral Maxillofac Surg. 2019 Oct;77(10):2154-2167
pubmed: 31014965
Clin Otolaryngol. 2018 Mar 25;:
pubmed: 29575685
Head Neck. 2015 Apr;37(4):573-8
pubmed: 24677355
Laryngoscope. 2008 Jul;118(7):1191-4
pubmed: 18391764
Cancer. 2013 Mar 15;119(6):1168-76
pubmed: 23184439
Eur Arch Otorhinolaryngol. 2017 Feb;274(2):961-968
pubmed: 27561671
Arch Otolaryngol Head Neck Surg. 1994 Jul;120(7):699-702
pubmed: 8018319
Oral Oncol. 2016 Feb;53:20-6
pubmed: 26631953
ORL J Otorhinolaryngol Relat Spec. 2004;66(1):38-41
pubmed: 15103200
Radiology. 1991 Aug;180(2):457-61
pubmed: 2068312
Histopathology. 2019 Sep;75(3):329-337
pubmed: 31021008
Cancer. 2009 Apr 1;115(7):1489-97
pubmed: 19197973
Oral Oncol. 2013 Aug;49(8):771-7
pubmed: 23735238
CA Cancer J Clin. 2017 Mar;67(2):93-99
pubmed: 28094848
Oral Oncol. 2018 Mar;78:94-101
pubmed: 29496065
N Engl J Med. 2015 Aug 6;373(6):521-9
pubmed: 26027881
Oral Oncol. 2015 Nov;51(11):963-965
pubmed: 26384540
Eur J Nucl Med Mol Imaging. 2019 Mar;46(3):623-637
pubmed: 30564849
Oral Oncol. 2019 Mar;90:87-93
pubmed: 30846183
JAMA Otolaryngol Head Neck Surg. 2014 Dec;140(12):1138-48
pubmed: 25075712