Neurovascular Inflammaging in Health and Disease.
aging
inflammaging
inflammasome
neurodegeneration
neuroinflammation
neurovascular unit
stroke
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
04 07 2020
04 07 2020
Historique:
received:
22
06
2020
accepted:
02
07
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
9
3
2021
Statut:
epublish
Résumé
Aging is characterized by a chronic low-grade sterile inflammation dubbed as inflammaging, which in part originates from accumulating cellular debris. These, acting as danger signals with many intrinsic factors such as cytokines, are sensed by a network of pattern recognition receptors and other cognate receptors, leading to the activation of inflammasomes. Due to the inflammasome activity-dependent increase in the levels of pro-inflammatory interleukins (IL-1β, IL-18), inflammation is initiated, resulting in tissue injury in various organs, the brain and the spinal cord included. Similarly, in age-related diseases of the central nervous system (CNS), inflammasome activation is a prominent moment, in which cells of the neurovascular unit occupy a significant position. In this review, we discuss the inflammatory changes in normal aging and summarize the current knowledge on the role of inflammasomes and contributing mechanisms in common CNS diseases, namely Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and stroke, all of which occur more frequently with aging.
Identifiants
pubmed: 32635451
pii: cells9071614
doi: 10.3390/cells9071614
pmc: PMC7407516
pii:
doi:
Substances chimiques
Inflammasomes
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Ageing Res Rev. 2013 Sep;12(4):941-66
pubmed: 24103368
J Gerontol A Biol Sci Med Sci. 2014 Jun;69 Suppl 1:S4-9
pubmed: 24833586
Mol Neurodegener. 2016 Apr 16;11:28
pubmed: 27084336
Elife. 2018 Jan 24;7:
pubmed: 29364116
Nat Med. 2009 Sep;15(9):1031-7
pubmed: 19718040
J Neuroinflammation. 2019 Jun 7;16(1):121
pubmed: 31174550
Glia. 2020 Feb;68(2):407-421
pubmed: 31596526
J Biol Chem. 2008 Mar 21;283(12):7745-53
pubmed: 18184658
J Neurosci. 2009 Nov 18;29(46):14553-70
pubmed: 19923289
J Neuroinflammation. 2019 Jul 10;16(1):142
pubmed: 31291966
Neuro Oncol. 2017 Sep 1;19(9):1173-1182
pubmed: 28541444
J Neurosci Res. 2008 Dec;86(16):3515-25
pubmed: 18683239
J Neurosci. 2010 Sep 22;30(38):12676-89
pubmed: 20861373
Brain Pathol. 2014 Jul;24(4):371-86
pubmed: 24946075
J Cereb Blood Flow Metab. 2017 Jun;37(6):2013-2024
pubmed: 27418036
Gerontology. 2019;65(5):495-504
pubmed: 31055573
Toxicol Appl Pharmacol. 2015 Dec 1;289(2):133-41
pubmed: 26431797
Behav Neurol. 2015;2015:891651
pubmed: 26246694
Neurobiol Aging. 2014 Oct;35(10):2249-62
pubmed: 24831823
Arch Immunol Ther Exp (Warsz). 2016 Apr;64(2):111-26
pubmed: 26658771
Brain. 2017 Jan;140(1):184-200
pubmed: 27818384
Neurobiol Dis. 2017 Nov;107:41-56
pubmed: 27425887
Cold Spring Harb Perspect Med. 2012 Aug 01;2(8):
pubmed: 22908195
Acta Neuropathol. 2017 Feb;133(2):303-319
pubmed: 27888296
J Biol Chem. 2008 Mar 21;283(12):7657-65
pubmed: 18211888
Neurobiol Aging. 2014 Feb;35(2):309-21
pubmed: 24054992
Cold Spring Harb Perspect Med. 2011 Sep;1(1):a006189
pubmed: 22229116
Nat Med. 2015 Aug;21(8):880-6
pubmed: 26214837
Neurochem Res. 2017 Apr;42(4):1104-1115
pubmed: 28247334
Neuroscience. 2018 Oct 15;390:218-230
pubmed: 30172704
Mov Disord. 2020 Jan;35(1):20-33
pubmed: 31680318
Cell Death Dis. 2014 Aug 21;5:e1382
pubmed: 25144717
Nat Rev Cardiol. 2018 Sep;15(9):505-522
pubmed: 30065258
Brain Res. 2015 Oct 14;1623:30-8
pubmed: 25916577
Int J Mol Sci. 2019 Sep 12;20(18):
pubmed: 31547225
Immun Ageing. 2015 Mar 07;12:2
pubmed: 25784952
Brain Pathol. 2017 Mar;27(2):220-222
pubmed: 28019679
Hum Mol Genet. 2017 Oct 1;26(R2):R105-R113
pubmed: 28977441
Nat Rev Neurosci. 2007 Jul;8(7):499-509
pubmed: 17551515
Brain Circ. 2016 Oct-Dec;2(4):153-163
pubmed: 30276293
Nature. 2013 May 9;497(7448):211-6
pubmed: 23636330
Sci Rep. 2019 Jan 15;9(1):133
pubmed: 30644421
J Neuroinflammation. 2012 Aug 16;9:199
pubmed: 22898493
Front Endocrinol (Lausanne). 2015 Feb 06;6:13
pubmed: 25705204
J Neuroinflammation. 2020 Jan 8;17(1):11
pubmed: 31915018
Neurotherapeutics. 2011 Jul;8(3):319-29
pubmed: 21691873
J Cereb Blood Flow Metab. 2020 May;40(5):1048-1060
pubmed: 31216943
Inflammation. 2018 Feb;41(1):93-103
pubmed: 28936769
Int Immunopharmacol. 2016 Nov;40:492-500
pubmed: 27769021
Neurobiol Dis. 2000 Dec;7(6 Pt B):682-9
pubmed: 11114266
Acta Neuropathol. 1983;60(3-4):232-40
pubmed: 6613533
Exp Suppl. 2018;108:303-320
pubmed: 30536177
Glia. 2013 Jul;61(7):1113-21
pubmed: 23625868
Ageing Res Rev. 2014 May;15:6-15
pubmed: 24561250
J Cereb Blood Flow Metab. 2010 Mar;30(3):480-92
pubmed: 20010958
Cell Death Differ. 2015 Oct;22(10):1676-86
pubmed: 25744023
Sci Rep. 2013 Nov 19;3:3254
pubmed: 24247109
Nature. 2013 Jan 31;493(7434):674-8
pubmed: 23254930
J Neuroinflammation. 2016 Jan 27;13:20
pubmed: 26818951
Proc Natl Acad Sci U S A. 2008 Oct 7;105(40):15605-10
pubmed: 18832152
Nat Med. 2011 Jul 07;17(7):796-808
pubmed: 21738161
Front Immunol. 2018 Jun 05;9:1283
pubmed: 29951054
Redox Biol. 2015 Dec;6:524-551
pubmed: 26484802
Curr Neuropharmacol. 2017;15(6):892-905
pubmed: 28088914
Cell Physiol Biochem. 2018;45(6):2351-2368
pubmed: 29554649
Neurochem Int. 2010 Nov;57(5):556-64
pubmed: 20637248
J Neurosci Res. 2020 Feb;98(2):299-311
pubmed: 30632202
Am J Physiol Heart Circ Physiol. 2017 Nov 1;313(5):H1000-H1012
pubmed: 28801521
Biochem Pharmacol. 2018 Dec;158:207-216
pubmed: 30393045
Int J Mol Sci. 2019 Nov 03;20(21):
pubmed: 31684130
J Biol Chem. 2017 Jan 20;292(3):762-770
pubmed: 27920202
Brain. 2017 Sep 1;140(9):2273-2285
pubmed: 29050380
Life Sci. 2020 Jun 15;251:117638
pubmed: 32251636
Nat Rev Dis Primers. 2019 Oct 10;5(1):70
pubmed: 31601801
Int Immunopharmacol. 2020 Jul;84:106547
pubmed: 32361652
Int J Mol Sci. 2016 Aug 29;17(9):
pubmed: 27589720
Nat Rev Neurol. 2018 Mar;14(3):133-150
pubmed: 29377008
Stroke. 2016 Aug;47(8):2160-7
pubmed: 26931154
Brain Behav Immun. 2019 Feb;76:236-247
pubmed: 30550933
Behav Brain Res. 2019 Jan 1;356:483-489
pubmed: 29885849
J Neural Transm (Vienna). 2018 Apr;125(4):615-650
pubmed: 29222591
Mol Immunol. 2020 Jul;123:74-87
pubmed: 32438202
Antioxid Redox Signal. 2015 Dec 10;23(17):1329-50
pubmed: 26067258
Brain Pathol. 2018 Jan;28(1):14-27
pubmed: 27880990
J Alzheimers Dis. 2016 Jun 15;54(1):45-53
pubmed: 27314526
N Engl J Med. 2001 May 31;344(22):1688-700
pubmed: 11386269
Proc Natl Acad Sci U S A. 2015 Mar 31;112(13):4050-5
pubmed: 25775556
Neurosci Lett. 2017 Jan 1;636:3-8
pubmed: 27150074
Nat Immunol. 2008 Aug;9(8):857-65
pubmed: 18604209
Front Aging Neurosci. 2018 Sep 19;10:275
pubmed: 30283329
Tissue Barriers. 2016 Jan 28;4(1):e1143544
pubmed: 27141424
Mol Neurobiol. 2017 Dec;54(10):8429-8443
pubmed: 27957680
Neural Regen Res. 2018 Oct;13(10):1719-1730
pubmed: 30136683
Front Neurosci. 2016 Sep 05;10:408
pubmed: 27656123
Geroscience. 2020 Apr;42(2):727-748
pubmed: 32172434
Mol Phylogenet Evol. 2017 Feb;107:232-238
pubmed: 27845203
Brain. 2020 Apr 1;143(4):1057-1072
pubmed: 31851317
Int J Mol Sci. 2014 Apr 16;15(4):6453-74
pubmed: 24743889
Glia. 2015 Dec;63(12):2260-73
pubmed: 26200799
Nature. 2014 Apr 3;508(7494):55-60
pubmed: 24670647
Semin Immunol. 2018 Dec;40:1-5
pubmed: 30392751
Int J Mol Sci. 2019 Jun 11;20(11):
pubmed: 31212645
Mol Neurobiol. 2018 Mar;55(3):2350-2361
pubmed: 28357805
J Neuroinflammation. 2012 Jul 23;9:179
pubmed: 22824372
Ther Adv Neurol Disord. 2018 May 22;11:1756286418774254
pubmed: 29854002
Cell Death Dis. 2013 Sep 05;4:e790
pubmed: 24008734
Immunity. 2012 Sep 21;37(3):487-500
pubmed: 22981536
Trends Endocrinol Metab. 2018 Jan;29(1):8-17
pubmed: 29150317
Nat Neurosci. 2016 May 26;19(6):771-83
pubmed: 27227366
Aging (Albany NY). 2019 Jun 17;11(12):3891-3892
pubmed: 31209185
Nat Commun. 2013;4:2932
pubmed: 24336108
Cell Death Dis. 2014 Aug 14;5:e1370
pubmed: 25118930
Exp Cell Res. 2020 Apr 15;389(2):111912
pubmed: 32084391
Clin Epidemiol. 2015 Feb 12;7:181-93
pubmed: 25709501
Neuroendocrinology. 2016;103(5):460-75
pubmed: 26337121
Nat Neurosci. 2007 May;10(5):535-7
pubmed: 17453052
Cell Rep. 2018 Jan 2;22(1):269-285
pubmed: 29298427
Prog Neurobiol. 2007 Dec;83(6):363-74
pubmed: 17913328
Transl Stroke Res. 2010 Mar 1;1(1):57-64
pubmed: 20596246
Front Aging Neurosci. 2018 Oct 26;10:337
pubmed: 30416441
J Neuroinflammation. 2011 Mar 25;8:26
pubmed: 21439035
Annu Rev Med. 2018 Jan 29;69:437-449
pubmed: 29106805
Ageing Res Rev. 2017 Mar;34:77-87
pubmed: 27697546
J Neuroinflammation. 2018 Aug 28;15(1):242
pubmed: 30153825
J Neurosci. 2017 Jan 4;37(1):129-140
pubmed: 28053036
Nat Rev Immunol. 2014 Jul;14(7):463-77
pubmed: 24962261
Front Cell Neurosci. 2017 Aug 08;11:227
pubmed: 28848393
Cell Mol Life Sci. 2012 Sep;69(18):2999-3013
pubmed: 22446749
Curr Alzheimer Res. 2011 Feb;8(1):67-80
pubmed: 21143158
J Neural Transm (Vienna). 2011 Nov;118(11):1575-83
pubmed: 21461961
Curr Opin Psychiatry. 2016 Mar;29(2):159-67
pubmed: 26828645
Neuron. 2006 Feb 16;49(4):489-502
pubmed: 16476660
Cell Metab. 2018 Jun 05;27(6):1176-1199
pubmed: 29874566
Trends Immunol. 2010 Jan;31(1):7-17
pubmed: 19879804
Biochem Biophys Res Commun. 2016 Oct 28;479(4):656-662
pubmed: 27693696
J Cereb Blood Flow Metab. 2014 Apr;34(4):660-7
pubmed: 24424382
Cell Mol Immunol. 2017 Jan;14(1):65-79
pubmed: 27345727
Nat Neurosci. 2017 Oct 26;20(11):1514-1515
pubmed: 29073642
CNS Neurol Disord Drug Targets. 2013 Aug;12(5):698-714
pubmed: 23469845
Neurobiol Dis. 2009 Apr;34(1):95-106
pubmed: 19162185
J Neuroimmunol. 2020 Jan 15;338:577089
pubmed: 31704453
Front Cell Neurosci. 2019 Apr 02;13:127
pubmed: 31001089
Immunol Invest. 2018 Nov;47(8):844-854
pubmed: 31282803
Brain Behav Immun. 2019 Jan;75:34-47
pubmed: 30195027
Acta Pharmacol Sin. 2019 Dec;40(12):1503-1512
pubmed: 31388087
Cell Metab. 2013 Oct 1;18(4):519-32
pubmed: 24093676
PeerJ. 2020 May 7;8:e9042
pubmed: 32419986
J Neuroinflammation. 2008 Feb 26;5:7
pubmed: 18302763
Immunol Rev. 2015 May;265(1):6-21
pubmed: 25879280
J Neuroimmunol. 2002 Mar;124(1-2):83-92
pubmed: 11958825
Nat Rev Neurol. 2019 Oct;15(10):565-581
pubmed: 31501588
CNS Neurosci Ther. 2019 Dec;25(12):1299-1307
pubmed: 31729181
J Neuroinflammation. 2014 May 23;11:94
pubmed: 24884937
Brain Behav Immun. 2017 Aug;64:220-231
pubmed: 28432035
Brain Behav Immun. 2018 Oct;73:66-84
pubmed: 29902514
J Cereb Blood Flow Metab. 2009 Mar;29(3):534-44
pubmed: 19066616
Exp Neurol. 2015 Nov;273:24-35
pubmed: 26222336
Am J Physiol Cell Physiol. 2018 Sep 1;315(3):C343-C356
pubmed: 29949404
Neurosci Res. 2011 Apr;69(4):337-42
pubmed: 21255620
Acta Myol. 2011 Jun;30(1):4-8
pubmed: 21842586
Curr Neuropharmacol. 2019;17(7):582-589
pubmed: 30592254
Int Immunol. 2015 Mar;27(3):117-29
pubmed: 25344935
Brain Res. 1999 Dec 18;851(1-2):215-20
pubmed: 10642846
Brain Res. 1998 Mar 2;785(2):195-206
pubmed: 9518610
Int Immunopharmacol. 2020 Jan;78:106015
pubmed: 31780369
Neuroscientist. 2018 Feb;24(1):73-83
pubmed: 28403673
J Neurochem. 1997 Mar;68(3):1135-41
pubmed: 9048759
Endocrinology. 2018 Aug 1;159(8):3120-3131
pubmed: 30010821
J Cereb Blood Flow Metab. 2016 Jun;36(6):1143-54
pubmed: 26661159
Int J Mol Sci. 2017 Aug 01;18(8):
pubmed: 28763002
Nat Med. 2019 Jun;25(6):988-1000
pubmed: 31086348
Proc Natl Acad Sci U S A. 2019 Sep 3;116(36):17963-17969
pubmed: 31427526
Ann N Y Acad Sci. 2000 Jun;908:244-54
pubmed: 10911963
Int J Stroke. 2019 Aug;14(6):574-591
pubmed: 30940045
Int Immunopharmacol. 2019 Feb;67:458-464
pubmed: 30594776
Lancet Neurol. 2011 Mar;10(3):253-63
pubmed: 21349440
EMBO Mol Med. 2020 Apr 7;12(4):e11002
pubmed: 32239625
CNS Neurosci Ther. 2019 Dec;25(12):1308-1317
pubmed: 31747126
Bull World Health Organ. 2016 Sep 1;94(9):634-634A
pubmed: 27708464
Aging (Albany NY). 2019 Jun 10;11(11):3785-3794
pubmed: 31182682
J Neuroinflammation. 2018 Sep 27;15(1):282
pubmed: 30261895
Exp Neurol. 2020 Jul;329:113302
pubmed: 32275928
Am J Pathol. 1999 Feb;154(2):337-42
pubmed: 10027392
J Neuroinflammation. 2011 Aug 26;8:106
pubmed: 21867555
Semin Immunol. 2018 Dec;40:61-73
pubmed: 30268598
NPJ Parkinsons Dis. 2018 Aug 15;4:24
pubmed: 30131971
Trends Endocrinol Metab. 2017 Mar;28(3):199-212
pubmed: 27789101
J Mol Neurosci. 2019 Nov;69(3):411-418
pubmed: 31267316
Handb Exp Pharmacol. 2009;(190):159-70
pubmed: 19096776
Sci Transl Med. 2018 Oct 31;10(465):
pubmed: 30381407
J Neuroinflammation. 2005 Jun 03;2:14
pubmed: 15935098
J Biomed Biotechnol. 2011;2011:464701
pubmed: 21331357