Probing the DNA Reactivity and the Anticancer Properties of a Novel Tubercidin-Pt(II) Complex.

CD spectroscopy DNA ESI-MS stability studies apoptosis cancer cell viability assay cisplatin nucleosides platinum complexes tubercidin

Journal

Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003

Informations de publication

Date de publication:
04 Jul 2020
Historique:
received: 21 05 2020
revised: 30 06 2020
accepted: 03 07 2020
entrez: 9 7 2020
pubmed: 9 7 2020
medline: 9 7 2020
Statut: epublish

Résumé

Herein, we reported on the synthesis of a novel Pt(II) neutral complex having as ligand the nucleoside tubercidin, a potent anti-tumor agent extracted from the bacterium

Identifiants

pubmed: 32635488
pii: pharmaceutics12070627
doi: 10.3390/pharmaceutics12070627
pmc: PMC7407906
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Regione Campania-POR Campania FESR 2014/2020 "Combattere la resistenza tumorale: piattaforma integrata multidisciplinare per un approccio tecnologico innovativo alle oncoterapie-Campania Oncoterapie" (Project N. B61G18000470007).
ID : B61G18000470007

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Auteurs

Stefano D'Errico (S)

CESTEV, University of Naples Federico II, via Tommaso De Amicis, 95, 80145 Napoli, Italy.

Andrea Patrizia Falanga (AP)

Dipartimento di Medicina Molecolare e Biotecnologie Mediche, University of Naples Federico II, via Sergio Pansini, 5, 80131 Napoli, Italy.

Domenica Capasso (D)

CESTEV, University of Naples Federico II, via Tommaso De Amicis, 95, 80145 Napoli, Italy.

Sonia Di Gaetano (S)

Istituto di Biostrutture e Bioimmagini, CNR, via Mezzocannone, 16, 80134 Napoli, Italy.

Maria Marzano (M)

Dipartimento di Farmacia, University of Naples Federico II, via Domenico Montesano, 49, 80131 Napoli, Italy.

Monica Terracciano (M)

Dipartimento di Farmacia, University of Naples Federico II, via Domenico Montesano, 49, 80131 Napoli, Italy.

Giovanni Nicola Roviello (GN)

Istituto di Biostrutture e Bioimmagini, CNR, via Mezzocannone, 16, 80134 Napoli, Italy.

Gennaro Piccialli (G)

Dipartimento di Farmacia, University of Naples Federico II, via Domenico Montesano, 49, 80131 Napoli, Italy.
ISBE-IT-Candidate National Node of Italy for ISBE, Research Infrastructure for Systems Biology Europe, University of Naples Federico II, via Domenico Montesano, 49, 80131 Napoli, Italy.

Giorgia Oliviero (G)

Dipartimento di Medicina Molecolare e Biotecnologie Mediche, University of Naples Federico II, via Sergio Pansini, 5, 80131 Napoli, Italy.
ISBE-IT-Candidate National Node of Italy for ISBE, Research Infrastructure for Systems Biology Europe, University of Naples Federico II, via Domenico Montesano, 49, 80131 Napoli, Italy.

Nicola Borbone (N)

Dipartimento di Farmacia, University of Naples Federico II, via Domenico Montesano, 49, 80131 Napoli, Italy.
ISBE-IT-Candidate National Node of Italy for ISBE, Research Infrastructure for Systems Biology Europe, University of Naples Federico II, via Domenico Montesano, 49, 80131 Napoli, Italy.

Classifications MeSH