UPF1-Mediated RNA Decay-Danse Macabre in a Cloud.
RNA turnover and surveillance
RNA-binding protein
UPF1
UPF1-mediated RNA decay
nonsense-mediated RNA decay
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
04 07 2020
04 07 2020
Historique:
received:
15
05
2020
revised:
18
06
2020
accepted:
29
06
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
20
4
2021
Statut:
epublish
Résumé
Nonsense-mediated RNA decay (NMD) is the prototype example of a whole family of RNA decay pathways that unfold around a common central effector protein called UPF1. While NMD in yeast appears to be a linear pathway, NMD in higher eukaryotes is a multifaceted phenomenon with high variability with respect to substrate RNAs, degradation efficiency, effector proteins and decay-triggering RNA features. Despite increasing knowledge of the mechanistic details, it seems ever more difficult to define NMD and to clearly distinguish it from a growing list of other UPF1-mediated RNA decay pathways (UMDs). With a focus on mammalian, we here critically examine the prevailing NMD models and the gaps and inconsistencies in these models. By exploring the minimal requirements for NMD and other UMDs, we try to elucidate whether they are separate and definable pathways, or rather variations of the same phenomenon. Finally, we suggest that the operating principle of the UPF1-mediated decay family could be considered similar to that of a computing cloud providing a flexible infrastructure with rapid elasticity and dynamic access according to specific user needs.
Identifiants
pubmed: 32635561
pii: biom10070999
doi: 10.3390/biom10070999
pmc: PMC7407380
pii:
doi:
Substances chimiques
Fungal Proteins
0
RNA, Messenger
0
Trans-Activators
0
RNA Helicases
EC 3.6.4.13
UPF1 protein, human
EC 3.6.4.13
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : NE 593/2-1 , NE 593/2-2
Pays : International
Déclaration de conflit d'intérêts
The authors declare no conflict of interest
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