Effect of Non-Surgical Periodontal Treatment on Oxidative Stress Markers in Leukocytes and Their Interaction with the Endothelium in Obese Subjects with Periodontitis: A Pilot Study.
dietary therapy
endothelial dysfunction
obesity
oxidative stress
periodontal treatment
periodontitis
reactive oxygen species
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
04 Jul 2020
04 Jul 2020
Historique:
received:
16
05
2020
revised:
30
06
2020
accepted:
01
07
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
9
7
2020
Statut:
epublish
Résumé
The primary objective of this pilot study was to evaluate the effect of non-surgical periodontal treatment. The secondary aim was to evaluate the effect of dietary therapy on both parameters of oxidative stress in leukocytes and leukocyte-endothelial cell interactions in an obese population. This was a pilot study with a before-and-after design. Forty-nine obese subjects with periodontitis were randomized by means of the minimization method and assigned to one of two groups, one of which underwent dietary therapy while the other did not. All the subjects underwent non-surgical periodontal treatment. We determined periodontal, inflammatory and oxidative stress parameters-total reactive oxygen species (ROS), superoxide production, intracellular Ca Periodontal treatment improved the periodontal health of all the patients, with a reduction in serum retinol-binding protein 4 (RBP4), total superoxide production and cytosolic Ca Whereas non-surgical periodontal treatment induces an improvement in leukocyte homeostasis, dietary therapy as an adjuvant reduces systemic inflammation and increases antioxidant status which, in turn, modulates leukocyte-endothelium dynamics.
Identifiants
pubmed: 32635585
pii: jcm9072117
doi: 10.3390/jcm9072117
pmc: PMC7408850
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Eur J Clin Invest. 2018 Aug;48(8):e12985
pubmed: 29924382
J Periodontol. 2009 Jun;80(6):901-6
pubmed: 19485819
Atherosclerosis. 2015 Jan;238(1):45-51
pubmed: 25437889
Atherosclerosis. 2015 Jun;240(2):335-44
pubmed: 25875385
Clin Exp Immunol. 2007 Feb;147(2):255-64
pubmed: 17223966
Eur J Pharmacol. 2015 Oct 15;765:355-65
pubmed: 26344475
Clin Oral Investig. 2017 Sep;21(7):2319-2325
pubmed: 27933445
Nat Rev Endocrinol. 2012 Oct;8(10):570-2
pubmed: 22945363
Oral Dis. 2018 Oct;24(7):1349-1357
pubmed: 29873864
PLoS One. 2014 Mar 20;9(3):e92739
pubmed: 24651174
Int J Obes (Lond). 2019 Nov;43(11):2200-2209
pubmed: 30622308
Atherosclerosis. 2009 May;204(1):23-5
pubmed: 18838136
Periodontol 2000. 2007;43:160-232
pubmed: 17214840
Nutr Neurosci. 2014 Sep;17(5):214-21
pubmed: 24075078
J Clin Periodontol. 2018 Dec;45(12):1448-1457
pubmed: 30362611
Arch Oral Biol. 2016 Feb;62:80-5
pubmed: 26655951
Lancet Diabetes Endocrinol. 2018 Dec;6(12):954-965
pubmed: 30472992
Circulation. 2004 Sep 21;110(12):1564-71
pubmed: 15364812
Front Physiol. 2017 May 30;8:351
pubmed: 28611683
Front Physiol. 2017 Nov 13;8:910
pubmed: 29180965
Med Clin (Barc). 2007 Feb 10;128(5):184-96; quiz 1 p following 200
pubmed: 17298782
J Periodontol. 2013 Jan;84(1):13-23
pubmed: 22348694
J Clin Periodontol. 2018 Mar;45(3):345-353
pubmed: 29265454
Mol Metab. 2019 Jan;19:24-33
pubmed: 30385096
Annu Rev Physiol. 2010;72:219-46
pubmed: 20148674
Niger Med J. 2019 May-Jun;60(3):133-137
pubmed: 31543565
Cell Death Dis. 2010 Jul 15;1:e54
pubmed: 21364659
Exp Biol Med (Maywood). 2013 Jun;238(6):713-22
pubmed: 23918883
Nat Rev Cardiol. 2009 Jun;6(6):399-409
pubmed: 19399028
N Engl J Med. 2007 Mar 1;356(9):911-20
pubmed: 17329698
Free Radic Biol Med. 2015 Jan;78:190-201
pubmed: 25463279
Biochem J. 2009 Jan 1;417(1):1-13
pubmed: 19061483
J Clin Periodontol. 2018 Dec;45(12):1429-1439
pubmed: 30362144
J Membr Biol. 2016 Aug;249(4):437-47
pubmed: 26956056
Front Physiol. 2017 Aug 23;8:600
pubmed: 28878685
J Periodontol. 2012 Jun;83(6):684-9
pubmed: 22014172
Atherosclerosis. 2012 May;222(1):196-201
pubmed: 22440543
Atherosclerosis. 2014 Sep;236(1):39-46
pubmed: 25014033
J Clin Periodontol. 2016 Aug;43(8):652-8
pubmed: 27168055
J Clin Periodontol. 2018 Jun;45 Suppl 20:S149-S161
pubmed: 29926495
J Am Dent Assoc. 2017 May;148(5):308-318
pubmed: 28284417
Aust Dent J. 2010 Mar;55(1):70-8
pubmed: 20415915
J Periodontol. 2017 Aug;88(8):778-787
pubmed: 28492359
Hypertension. 2014 Oct;64(4):702-8
pubmed: 24958498
J Dent Res. 2007 Aug;86(8):718-22
pubmed: 17652198
J Periodontol. 2017 May;88(5):493-501
pubmed: 27976595
J Clin Periodontol. 2018 Mar;45(3):336-344
pubmed: 29150947
J Periodontol. 2018 Feb;89(2):176-185
pubmed: 28914596
Clin Oral Investig. 2016 Jul;20(6):1263-9
pubmed: 26434651
J Clin Periodontol. 2009 Jul;36 Suppl 10:15-9
pubmed: 19432627
Clin Oral Investig. 2017 Jul;21(6):1961-1969
pubmed: 27807715
Circulation. 2013 May 14;127(19):1938-47
pubmed: 23584360
Circ Res. 2008 Feb 29;102(4):401-14
pubmed: 18309108