Curcumin-1,2,3-Triazole Conjugation for Targeting the Cancer Apoptosis Machinery.
Antineoplastic Agents
/ chemistry
Apoptosis
Cell Proliferation
Curcumin
/ chemistry
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Humans
Leukemia, T-Cell
/ drug therapy
Membrane Potential, Mitochondrial
/ drug effects
Molecular Structure
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/ drug therapy
Structure-Activity Relationship
Triazoles
/ chemistry
Tumor Cells, Cultured
apoptosis
cell cycle
cell death
click chemistry
curcumin
flow cytometry
fluorine
privileged structure
triazole
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
05 Jul 2020
05 Jul 2020
Historique:
received:
27
05
2020
revised:
25
06
2020
accepted:
02
07
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
27
3
2021
Statut:
epublish
Résumé
The burden of neoplastic diseases is widely recognized as a severe cause of mortality. The clinical inadequacy of most anticancer therapeutics urgently prompted intense drug discovery efforts toward the identification of new chemical entities endowed with a potent and safe antitumor profile. In this scenario, targeting cancer cells apoptosis machinery has emerged as a relevant strategy, useful for tackling the emergence of drug resistance. On this basis, a small library of naturally inspired hybrid molecules was obtained by combining, through a click chemistry approach, "privileged" synthons such as curcumin scaffold and 1,2,3-triazole building block. Compound
Identifiants
pubmed: 32635622
pii: molecules25133066
doi: 10.3390/molecules25133066
pmc: PMC7412087
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Triazoles
0
Curcumin
IT942ZTH98
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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