Human mesenchymal stem cells inhibit the differentiation and effector functions of monocytes.
Antigen Presentation
Cell Differentiation
Cell Proliferation
Cells, Cultured
Coculture Techniques
Dendritic Cells
/ immunology
Humans
Immunomodulation
Immunotherapy
/ methods
Inflammation
/ immunology
Lymphocyte Activation
Macrophages
/ immunology
Mesenchymal Stem Cells
/ physiology
Monocytes
/ immunology
Phagocytosis
T-Lymphocytes
/ immunology
Umbilical Cord
/ cytology
Mesenchymal stem cells
antigen presentation
immunosuppression
monocytes
phagocytosis
Journal
Innate immunity
ISSN: 1753-4267
Titre abrégé: Innate Immun
Pays: United States
ID NLM: 101469670
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
16
6
2021
Statut:
ppublish
Résumé
Although monocytes represent an essential part of the host defence system, their accumulation and prolonged stimulation could be detrimental and may aggravate chronic inflammatory diseases. The present study has explored the less-understood immunomodulatory effects of mesenchymal stem cells on monocyte functions. Isolated purified human monocytes were co-cultured with human umbilical cord-derived mesenchymal stem cells under appropriate culture conditions to assess monocytes' vital functions. Based on the surface marker analysis, mesenchymal stem cells halted monocyte differentiation into dendritic cells and macrophages and reduced their phagocytosis functions, which rendered an inability to stimulate T-cell proliferation. The present study confers that mesenchymal stem cells exerted potent immunosuppressive activity on monocyte functions such as differentiation, phagocytosis and Ag presentation; hence, they promise a potential therapeutic role in down-regulating the unwanted monocyte-mediated immune responses in the context of chronic inflammatory diseases.
Identifiants
pubmed: 32635840
doi: 10.1177/1753425919899132
pmc: PMC7903531
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
424-434Références
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