A novel humanized mouse model to study the function of human cutaneous memory T cells in vivo in human skin.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
07 07 2020
07 07 2020
Historique:
received:
20
05
2019
accepted:
01
06
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Human skin contains a population of memory T cells that supports tissue homeostasis and provides protective immunity. The study of human memory T cells is often restricted to in vitro studies and to human PBMC serving as primary cell source. Because the tissue environment impacts the phenotype and function of memory T cells, it is crucial to study these cells within their tissue. Here we utilized immunodeficient NOD-scid IL2rγ
Identifiants
pubmed: 32636404
doi: 10.1038/s41598-020-67430-7
pii: 10.1038/s41598-020-67430-7
pmc: PMC7341892
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
11164Subventions
Organisme : NIAID NIH HHS
ID : R01 AI127726
Pays : United States
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