Next-Generation Manufacturing Protocols Enriching T
B-ALL and PDAC
CAR T
CAR T cell fitness
CAR T cell manufacturing
CAR design
patient samples
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
02
03
2020
accepted:
15
05
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
7
4
2021
Statut:
epublish
Résumé
Chimeric antigen receptor (CAR) T cell expansion and persistence emerged as key efficacy determinants in cancer patients. These features are typical of early-memory T cells, which can be enriched with specific manufacturing procedures, providing signal one and signal two in the proper steric conformation and in the presence of homeostatic cytokines. In this project, we exploited our expertise with paramagnetic beads and IL-7/IL-15 to develop an optimized protocol for CAR T cell production based on reagents, including a polymeric nanomatrix, which are compatible with automated manufacturing
Identifiants
pubmed: 32636841
doi: 10.3389/fimmu.2020.01217
pmc: PMC7317024
doi:
Substances chimiques
Receptors, Chimeric Antigen
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1217Informations de copyright
Copyright © 2020 Arcangeli, Falcone, Camisa, De Girardi, Biondi, Giglio, Ciceri, Bonini, Bondanza and Casucci.
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