Fifteen Years of Sm-p80-Based Vaccine Trials in Nonhuman Primates: Antibodies From Vaccinated Baboons Confer Protection
Schistosoma mansoni
Sm-p80 vaccine
baboons
passive transfer
schistosomiasis
systems biology
transcriptomics
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
15
03
2020
accepted:
18
05
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
7
4
2021
Statut:
epublish
Résumé
Recent advances in systems biology have shifted vaccine development from a largely trial-and-error approach to an approach that promote rational design through the search for immune signatures and predictive correlates of protection. These advances will doubtlessly accelerate the development of a vaccine for schistosomiasis, a neglected tropical disease that currently affects over 250 million people. For over 15 years and with contributions of over 120 people, we have endeavored to test and optimize Sm-p80-based vaccines in the non-human primate model of schistosomiasis. Using RNA-sequencing on eight different Sm-p80-based vaccine strategies, we sought to elucidate immune signatures correlated with experimental protective efficacy. Furthermore, we aimed to explore the role of antibodies through
Identifiants
pubmed: 32636844
doi: 10.3389/fimmu.2020.01246
pmc: PMC7318103
doi:
Substances chimiques
Antibodies, Helminth
0
Antigens, Helminth
0
Vaccines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1246Subventions
Organisme : NIAID NIH HHS
ID : R01 AI071223
Pays : United States
Organisme : NIAID NIH HHS
ID : R43 AI103983
Pays : United States
Organisme : NIAID NIH HHS
ID : R44 AI103983
Pays : United States
Organisme : NIAID NIH HHS
ID : R43 AI142908
Pays : United States
Informations de copyright
Copyright © 2020 Zhang, Le, Ahmad, Molehin, Siddiqui, Torben, Karmakar, Rojo, Sennoune, Lazarus, Khatoon, Freeborn, Sudduth, Rezk, Carey, Wolf, Papin, Damian, Gray, Marks, Carter and Siddiqui.
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