An update on serum biomarkers to assess axial spondyloarthritis and to guide treatment decision.
ankylosing spondylitis
anti-drug antibodies
axial spondyloarthritis
biomarkers
disease activity
radiographic progression
Journal
Therapeutic advances in musculoskeletal disease
ISSN: 1759-720X
Titre abrégé: Ther Adv Musculoskelet Dis
Pays: England
ID NLM: 101517322
Informations de publication
Date de publication:
2020
2020
Historique:
received:
12
03
2020
accepted:
22
05
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
9
7
2020
Statut:
epublish
Résumé
Axial spondyloarthritis (axSpA) is a group of debilitating, chronic, rheumatic conditions characterized by inflammation and new bone formation, mainly involving the spine and the sacroiliac joints. The lack of biomarkers in axSpA is well known. Despite significant treatment advances in recent years thanks to the introduction of drugs with a new mode of action, such as new biologic and targeted synthetic disease-modifying antirheumatic drugs, no relevant improvement in the identification of disease biomarkers has been achieved. Common parameters, such as erythrocyte sedimentation rate and C-reactive protein, which are routinely used to measure systemic inflammation, are the sole markers available to date and are not adequate to assess disease activity in all patients. The aim of this study is to review the most promising serum biomarkers that may help treatment decision in axSpA
Identifiants
pubmed: 32636944
doi: 10.1177/1759720X20934277
pii: 10.1177_1759720X20934277
pmc: PMC7315656
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1759720X20934277Informations de copyright
© The Author(s), 2020.
Déclaration de conflit d'intérêts
Conflict of interest statement: The authors declare that there is no conflict of interest.
Références
Arthritis Rheum. 2012 May;64(5):1388-98
pubmed: 22127957
Clin Exp Immunol. 2019 May;196(2):259-275
pubmed: 30656642
Rheumatology (Oxford). 2018 Apr 1;57(4):688-693
pubmed: 29365183
Rheumatology (Oxford). 2019 May 1;58(5):811-819
pubmed: 30561738
Clin Rheumatol. 2010 Oct;29(10):1155-61
pubmed: 20690034
J Rheumatol. 2013 Dec;40(12):2029-37
pubmed: 24187103
PLoS One. 2010 Sep 03;5(9):
pubmed: 20844595
Ann Rheum Dis. 2014 May;73(5):817-23
pubmed: 24389297
Mol Cells. 2017 Oct;40(10):706-713
pubmed: 29047262
Ann Rheum Dis. 2016 Nov;75(11):1984-1988
pubmed: 27098404
Ann Rheum Dis. 2014 Jun;73(6):1211-4
pubmed: 23687263
Scand J Gastroenterol. 2012 Apr;47(4):435-44
pubmed: 22229862
J Investig Med. 2013 Jun;61(5):848-51
pubmed: 23552178
Rheumatology (Oxford). 2014 Feb;53(2):213-22
pubmed: 23946436
Int J Clin Exp Med. 2015 Oct 15;8(10):17362-76
pubmed: 26770328
Clin Pharmacol Ther. 2001 Mar;69(3):89-95
pubmed: 11240971
Clin Exp Rheumatol. 2014 Sep-Oct;32(5):640-6
pubmed: 25190453
Arthritis Care Res (Hoboken). 2019 Jan;71(1):2-29
pubmed: 30499259
Reumatismo. 2017 Aug 03;69(2):65-74
pubmed: 28776360
Exp Biol Med (Maywood). 2013 Dec;238(12):1431-6
pubmed: 24146263
Biomed Res Int. 2015;2015:604872
pubmed: 26064930
Clin Rheumatol. 2000;19(2):92-8
pubmed: 10791618
Dis Markers. 2017;2017:7574147
pubmed: 28630526
Arthritis Rheum. 2009 May;60(5):1324-30
pubmed: 19404933
Arthritis Rheum. 2013 Apr;65(4):972-80
pubmed: 23280360
Ann Rheum Dis. 2018 Apr;77(4):484-487
pubmed: 28939629
Exp Biol Med (Maywood). 2017 Apr;242(8):859-873
pubmed: 27895095
Rheumatology (Oxford). 2010 Jun;49(6):1107-11
pubmed: 20223813
BMJ. 2010 Jul 15;341:c3369
pubmed: 20634346
Scand J Rheumatol. 2013;42(3):226-31
pubmed: 23409750
RMD Open. 2017 Jan 11;3(1):e000319
pubmed: 28123777
Ann Rheum Dis. 2011 Jun;70(6):896-904
pubmed: 21540199
Lancet. 2013 Nov 23;382(9906):1705-13
pubmed: 24035250
J Investig Med. 2014 Aug;62(6):880-4
pubmed: 24922195
Rheumatol Int. 2009 Sep;29(11):1343-7
pubmed: 19247658
Arthritis Rheum. 2009 Nov 15;61(11):1484-90
pubmed: 19877087
Sci Rep. 2019 Aug 2;9(1):11218
pubmed: 31375691
Clin Rheumatol. 2015 Jun;34(6):1009-18
pubmed: 25939520
Arthritis Rheum. 2004 Sep;50(9):2942-53
pubmed: 15457463
Ann Rheum Dis. 2012 Apr;71(4):572-4
pubmed: 22186710
Arthritis Res Ther. 2013 Jul 26;15(4):R79
pubmed: 23890223
J Rheumatol. 1999 Apr;26(4):980-4
pubmed: 10229432
BMC Musculoskelet Disord. 2012 Oct 02;13:191
pubmed: 23025387
Sci Rep. 2018 May 16;8(1):7731
pubmed: 29769586
BMJ. 2015 Nov 26;351:h5079
pubmed: 26612523
Rheumatol Int. 2019 Jan;39(1):111-119
pubmed: 30443744
Ann Rheum Dis. 1993 May;52(5):343-6
pubmed: 8323382
Clin Biochem. 2013 Nov;46(16-17):1778-9
pubmed: 24012856
Arthritis Rheum. 2011 Dec;63(12):3789-800
pubmed: 22127697
J Rheumatol. 2004 Nov;31(11):2236-41
pubmed: 15517638
N Engl J Med. 2015 Dec 24;373(26):2534-48
pubmed: 26699169
J Clin Immunol. 2013 Jan;33(1):151-61
pubmed: 22926407
Rheumatology (Oxford). 2019 Oct 1;58(10):1746-1754
pubmed: 31220322
Arthritis Res Ther. 2009;11(4):R101
pubmed: 19570209
Ann Rheum Dis. 2009 Jun;68(6):770-6
pubmed: 19297345
Clin Exp Rheumatol. 2018 Mar-Apr;36(2):228-232
pubmed: 29185966
Arthritis Rheumatol. 2015 Mar;67(3):678-85
pubmed: 25417763
Arthritis Rheum. 2009 Nov;60(11):3257-62
pubmed: 19877044
Arthritis Res Ther. 2010;12(4):R148
pubmed: 20642840
J Rheumatol. 2014 Jul;41(7):1349-56
pubmed: 24931960
Ann Rheum Dis. 2005 Nov;64(11):1568-75
pubmed: 15829577
Semin Arthritis Rheum. 2016 Apr;45(5):519-32
pubmed: 26607440
Ann Rheum Dis. 2009 Aug;68(8):1334-9
pubmed: 18678577
Rheumatology (Oxford). 2019 Sep 1;58(9):1556-1564
pubmed: 30830164
Mediators Inflamm. 2013;2013:828354
pubmed: 24453429
Arthritis Rheum. 2013 Oct;65(10):2645-54
pubmed: 23818109
Front Immunol. 2019 Mar 07;10:305
pubmed: 30899255
Ann Med. 2011 Nov;43(7):503-11
pubmed: 21585245
Lancet. 2017 Jul 1;390(10089):73-84
pubmed: 28110981
J Rheumatol. 2011 Aug;38(8):1644-50
pubmed: 21632677
Clin Exp Rheumatol. 2013 May-Jun;31(3):365-71
pubmed: 23294554
J Rheumatol. 2008 Oct;35(10):2030-7
pubmed: 18785308
J Dermatol. 2013 May;40(5):389-92
pubmed: 23414225
N Engl J Med. 2003 Feb 13;348(7):601-8
pubmed: 12584368
BMC Musculoskelet Disord. 2015 Jul 24;16:166
pubmed: 26205000
Rheumatology (Oxford). 2006 Oct;45(10):1197-200
pubmed: 16567356
Clin Rheumatol. 2015 Jun;34(6):1019-23
pubmed: 25939522
Scand J Rheumatol. 2015;44(2):118-24
pubmed: 25756521
Clin Exp Immunol. 2003 Apr;132(1):158-62
pubmed: 12653851
Rheumatology (Oxford). 2008 Dec;47(12):1775-9
pubmed: 18854347
Joint Bone Spine. 2008 Oct;75(5):559-62
pubmed: 18674944
Ann Rheum Dis. 2009 Jun;68(6):777-83
pubmed: 19297344
Clin Exp Rheumatol. 2019 May-Jun;37(3):358-366
pubmed: 30767876
Expert Rev Clin Immunol. 2019 Feb;15(2):123-134
pubmed: 30576610
Arthritis Rheum. 2004 Oct 15;51(5):691-9
pubmed: 15478146
Int J Mol Sci. 2017 Apr 14;18(4):
pubmed: 28420081
Arthritis Rheum. 2009 Mar;60(3):717-27
pubmed: 19248087
PLoS One. 2011;6(10):e25900
pubmed: 21991382
Arthritis Res Ther. 2016 Nov 25;18(1):275
pubmed: 27887637
Arthritis Rheum. 2013 Jun;65(6):1522-9
pubmed: 23508523
Ann Rheum Dis. 2014 Dec;73(12):2137-43
pubmed: 23956246
Clin Rheumatol. 2011 Dec;30(12):1583-8
pubmed: 21968692
Clin Biochem. 2012 May;45(7-8):541-6
pubmed: 22382088
Arthritis Rheum. 1995 Apr;38(4):499-505
pubmed: 7718003
Clin Lab. 2014;60(9):1527-31
pubmed: 25291949
Ann Rheum Dis. 2010 Jul;69(7):1338-41
pubmed: 20498207
Am J Hypertens. 2012 Jun;25(6):644-50
pubmed: 22378036
Arthritis Res Ther. 2016 Dec 28;18(1):304
pubmed: 28031053
Yonsei Med J. 2008 Apr 30;49(2):288-94
pubmed: 18452267
Rheumatology (Oxford). 2015 Apr;54(4):728-35
pubmed: 25288779
Ann Rheum Dis. 2010 May;69(5):817-21
pubmed: 19581278
Arthritis Rheum. 2009 May 15;61(5):569-76
pubmed: 19405015
Arthritis Rheum. 2007 Jun;56(6):1846-53
pubmed: 17530713
Ann Rheum Dis. 2012 Apr;71(4):518-23
pubmed: 21989544
Clin Exp Rheumatol. 2017 May-Jun;35(3):415-422
pubmed: 27974096
Clin Pharmacol Ther. 2012 Apr;91(4):635-46
pubmed: 22357456
Semin Arthritis Rheum. 2017 Oct;47(2):183-192
pubmed: 28413099
Front Med (Lausanne). 2017 Jan 27;4:5
pubmed: 28191455
Ann Rheum Dis. 2014 Jun;73(6):1079-82
pubmed: 23644552
Ann Rheum Dis. 2017 Aug;76(8):1340-1347
pubmed: 28130206
Ann Rheum Dis. 2013 Feb;72(2):165-78
pubmed: 23178294
Arthritis Res Ther. 2018 Mar 1;20(1):38
pubmed: 29490705
Arthritis Res Ther. 2014 Aug 19;16(4):413
pubmed: 25135077
J Rheumatol. 1999 Apr;26(4):966-70
pubmed: 10229429
Drugs. 2019 Mar;79(4):433-443
pubmed: 30793255
Arthritis Rheum. 2006 Mar;54(3):711-5
pubmed: 16508927
Ann Rheum Dis. 2014 Oct;73(10):1873-9
pubmed: 23894062
Ann Rheum Dis. 2017 Jun;76(6):1070-1077
pubmed: 27965257
Clin Rheumatol. 2012 Aug;31(8):1231-8
pubmed: 22644087
Autoimmun Rev. 2011 Oct;10(12):773-8
pubmed: 21684355
Arthritis Res Ther. 2017 Jun 15;19(1):140
pubmed: 28619118
PLoS One. 2012;7(4):e31000
pubmed: 22485125
Ann Rheum Dis. 2006 Jun;65(6):713-20
pubmed: 16249231
Ann Rheum Dis. 2014 Sep;73(9):1746-8
pubmed: 24845387
Rheumatol Int. 2012 Feb;32(2):387-93
pubmed: 21116820
Arthritis Rheumatol. 2019 Feb;71(2):258-270
pubmed: 30225992
Clin Rheumatol. 2010 Nov;29(11):1301-9
pubmed: 20640910
Rheumatol Int. 2016 Apr;36(4):541-9
pubmed: 26620690
Clin Exp Rheumatol. 2011 Sep-Oct;29(5):828-34
pubmed: 22041179
Ann Rheum Dis. 2018 Jan;77(1):63-69
pubmed: 28939631
PLoS One. 2015 Aug 27;10(8):e0134974
pubmed: 26313358
Rev Bras Reumatol Engl Ed. 2017 Jul - Aug;57(4):311-319
pubmed: 28743358
Reumatol Clin. 2018 Oct 29;:
pubmed: 30385295
Clinics (Sao Paulo). 2014 Dec;69(10):688-93
pubmed: 25518021
Int Immunopharmacol. 2014 Aug;21(2):481-6
pubmed: 24925756
J Chin Med Assoc. 2012 Jul;75(7):303-8
pubmed: 22824043
Nature. 2007 Jul 26;448(7152):484-487
pubmed: 17581588
Ann Rheum Dis. 2011 Aug;70(8):1375-81
pubmed: 21551511
Expert Opin Biol Ther. 2018 May;18(5):575-584
pubmed: 29533116
Clin Rheumatol. 2007 Sep;26(9):1427-32
pubmed: 17260105
Clin Rheumatol. 2013 Oct;32(10):1429-35
pubmed: 23887439
Ann Rheum Dis. 2013 Aug;72(8):1430-2
pubmed: 23625981
Arthritis Res Ther. 2012 May 28;14(3):R127
pubmed: 22640827
Ann Rheum Dis. 2016 Aug;75(8):1486-93
pubmed: 26462728
Bosn J Basic Med Sci. 2016 Jan 01;16(1):71-4
pubmed: 26773186
Immunol Res. 2017 Feb;65(1):419-422
pubmed: 27449503
PLoS One. 2017 Jun 22;12(6):e0177231
pubmed: 28640818
Arthritis Rheum. 2010 Jan;62(1):150-8
pubmed: 20039407
Autoimmun Rev. 2016 Jun;15(6):501-9
pubmed: 26851549
Rheumatology (Oxford). 2008 Aug;47(8):1219-22
pubmed: 18539620
Rheumatology (Oxford). 2019 Apr 1;58(4):729-730
pubmed: 30649542
J Rheumatol. 2018 May;45(5):630-637
pubmed: 29419466
Ann Rheum Dis. 2017 Mar;76(3):571-592
pubmed: 27582421
BioDrugs. 2015 Aug;29(4):241-58
pubmed: 26280210
Rheumatol Int. 2012 Aug;32(8):2523-7
pubmed: 21833531
PLoS One. 2018 Mar 26;13(3):e0194693
pubmed: 29579081
Clin Rheumatol. 2009 Feb;28(2):187-90
pubmed: 18827961
Clin Rheumatol. 2007 Feb;26(2):211-5
pubmed: 16583185
Arthritis Res Ther. 2017 Sep 21;19(1):210
pubmed: 28934972
Osteoporos Int. 2019 Feb;30(2):441-449
pubmed: 30306221
Joint Bone Spine. 2014 Oct;81(5):421-5
pubmed: 24703399
Rheumatology (Oxford). 2018 Aug 1;57(8):1390-1399
pubmed: 29718421
J Rheumatol. 2009 Aug;36(8):1575-9
pubmed: 19567627
Auto Immun Highlights. 2017 Dec;8(1):10
pubmed: 28702930
Front Med (Lausanne). 2019 Aug 07;6:177
pubmed: 31440510
Ann Rheum Dis. 2011 Feb;70(2):284-8
pubmed: 21068090
Rheumatol Int. 2016 Apr;36(4):575-8
pubmed: 26815206
Ann Rheum Dis. 2007 Jan;66(1):133-4
pubmed: 17178760
J Rheumatol. 2020 Apr;47(4):539-547
pubmed: 31203228
Ann Rheum Dis. 2008 Apr;67(4):511-7
pubmed: 17644552
Rheumatol Int. 2012 Jun;32(6):1711-20
pubmed: 21431945
RMD Open. 2018 May 14;4(1):e000648
pubmed: 29765702
Nat Med. 2007 Feb;13(2):156-63
pubmed: 17237793
Ann Rheum Dis. 2013 Dec;72(12):1947-55
pubmed: 23223420
Rheumatology (Oxford). 2006 Apr;45(4):414-20
pubmed: 16287916
J Rheumatol. 2009 Aug;36(8):1792-9
pubmed: 19671814
Arthritis Res Ther. 2016 Nov 16;18(1):265
pubmed: 27852321
Rheumatol Int. 2000;19(4):119-22
pubmed: 10836520
Ann Rheum Dis. 2015 Jan;74(1):52-9
pubmed: 23956249
Arthritis Res Ther. 2012 Oct 12;14(5):R216
pubmed: 23062122