Dual-energy computed-tomography-based discrimination between basic calcium phosphate and calcium pyrophosphate crystal deposition
Raman spectroscopy
basic calcium phosphate
calcium hydroxyapatite
calcium pyrophosphate
crystal-associated arthropathies
dual-energy computed tomography
Journal
Therapeutic advances in musculoskeletal disease
ISSN: 1759-720X
Titre abrégé: Ther Adv Musculoskelet Dis
Pays: England
ID NLM: 101517322
Informations de publication
Date de publication:
2020
2020
Historique:
received:
14
03
2020
accepted:
30
05
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
9
7
2020
Statut:
epublish
Résumé
Dual-energy computed tomography (DECT) is being considered as a non-invasive diagnostic and characterization tool in calcium crystal-associated arthropathies. Our objective was to assess the potential of DECT in distinguishing between basic calcium phosphate (BCP) and calcium pyrophosphate (CPP) crystal deposition in and around joints A total of 13 patients with calcific periarthritis and 11 patients with crystal-proven CPPD were recruited prospectively to undergo DECT scans. Samples harvested from BCP and CPP calcification types were analyzed using Raman spectroscopy and validated against synthetic crystals. Regions of interest were placed in BCP and CPP calcifications, and the following DECT attenuation parameters were obtained: CT numbers (HU) at 80 and 140 kV, dual-energy index (DEI), electron density (Rho), and effective atomic number ( Raman spectroscopy enabled chemical fingerprinting of BCP and CPP crystals both DECT can help distinguish between crystal-proven BCP and CPP calcification types
Sections du résumé
BACKGROUND
BACKGROUND
Dual-energy computed tomography (DECT) is being considered as a non-invasive diagnostic and characterization tool in calcium crystal-associated arthropathies. Our objective was to assess the potential of DECT in distinguishing between basic calcium phosphate (BCP) and calcium pyrophosphate (CPP) crystal deposition in and around joints
METHODS
METHODS
A total of 13 patients with calcific periarthritis and 11 patients with crystal-proven CPPD were recruited prospectively to undergo DECT scans. Samples harvested from BCP and CPP calcification types were analyzed using Raman spectroscopy and validated against synthetic crystals. Regions of interest were placed in BCP and CPP calcifications, and the following DECT attenuation parameters were obtained: CT numbers (HU) at 80 and 140 kV, dual-energy index (DEI), electron density (Rho), and effective atomic number (
RESULTS
RESULTS
Raman spectroscopy enabled chemical fingerprinting of BCP and CPP crystals both
CONCLUSION
CONCLUSIONS
DECT can help distinguish between crystal-proven BCP and CPP calcification types
Identifiants
pubmed: 32636945
doi: 10.1177/1759720X20936060
pii: 10.1177_1759720X20936060
pmc: PMC7315653
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1759720X20936060Informations de copyright
© The Author(s), 2020.
Déclaration de conflit d'intérêts
Conflict of interest statement: FB has received consulting fees from Horizon Therapeutics, unrelated to this work. The other authors declare that they have no competing interests.
Références
Orthopade. 1995 Jun;24(3):284-302
pubmed: 7617385
Ann Rheum Dis. 2018 Aug;77(8):1194-1199
pubmed: 29535120
Arthritis Res Ther. 2013;15(5):R103
pubmed: 24004678
Osteoarthritis Cartilage. 2019 Sep;27(9):1309-1314
pubmed: 31146015
Ann Rheum Dis. 2020 Jan;79(1):31-38
pubmed: 31167758
Nat Rev Rheumatol. 2018 Oct;14(10):592-602
pubmed: 30190520
Arthritis Rheumatol. 2018 Aug;70(8):1182-1191
pubmed: 29609209
Arthritis Rheum. 2011 Jan;63(1):10-8
pubmed: 20862682
Bone. 2005 May;36(5):893-901
pubmed: 15814305
Rheumatology (Oxford). 2016 Feb;55(2):379-80
pubmed: 26342227
Rheumatology (Oxford). 2019 Jun 1;58(6):1095-1098
pubmed: 30690553
Med Phys. 2020 Apr 24;:
pubmed: 32330301
Semin Musculoskelet Radiol. 2015 Dec;19(5):431-7
pubmed: 26696081
Arthritis Res Ther. 2017 Jul 21;19(1):171
pubmed: 28732526
Joint Bone Spine. 2019 Nov;86(6):665-668
pubmed: 31067507
Curr Rheumatol Rep. 2020 Apr 15;22(5):15
pubmed: 32291581
Rheumatology (Oxford). 2010 Mar;49(3):548-55
pubmed: 20032222
J Rheumatol. 2006 Feb;33(2):326-32
pubmed: 16465665
Arthritis Rheum. 2009 Sep;60(9):2694-703
pubmed: 19714647
Insights Imaging. 2018 Aug;9(4):477-492
pubmed: 29882050
N Engl J Med. 2016 Jun 30;374(26):2575-84
pubmed: 27355536
Rheumatology (Oxford). 2020 Jun 13;:
pubmed: 32533188
Arthritis Rheumatol. 2016 Jul;68(7):1751-7
pubmed: 26882173
AJR Am J Roentgenol. 2017 Nov;209(5):1088-1092
pubmed: 28834448
Arthritis Rheumatol. 2019 Jul;71(7):1158-1162
pubmed: 30714678
Rheumatology (Oxford). 2020 Apr 1;59(4):900-903
pubmed: 31630175
Radiology. 2018 Nov;289(2):293-312
pubmed: 30179101