Curcumin prevents chronic intermittent hypoxia-induced myocardial injury.
curcumin
intermittent hypoxia
myocardial injury
Journal
Therapeutic advances in chronic disease
ISSN: 2040-6223
Titre abrégé: Ther Adv Chronic Dis
Pays: United States
ID NLM: 101532140
Informations de publication
Date de publication:
2020
2020
Historique:
received:
12
10
2019
accepted:
24
03
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
9
7
2020
Statut:
epublish
Résumé
Chronic intermittent hypoxia (IH), the hallmark feature of obstructive sleep apnoea syndrome, contributes to infarct size enhancement after myocardial ischemia-reperfusion (I/R). Curcumin (Curc), the natural pigment of Swiss/SV129 mice were exposed to normoxia or IH (21-5% FiO IH increased nuclear HIF-1α expression and superoxide anion (O Curc prevents IH-induced myocardial cell death signalling. Curc might be used as a combined therapy with continuous positive airway pressure in sleep apnoea patients with high cardiovascular risk.
Sections du résumé
BACKGROUND
BACKGROUND
Chronic intermittent hypoxia (IH), the hallmark feature of obstructive sleep apnoea syndrome, contributes to infarct size enhancement after myocardial ischemia-reperfusion (I/R). Curcumin (Curc), the natural pigment of
METHODS
METHODS
Swiss/SV129 mice were exposed to normoxia or IH (21-5% FiO
RESULTS
RESULTS
IH increased nuclear HIF-1α expression and superoxide anion (O
CONCLUSION
CONCLUSIONS
Curc prevents IH-induced myocardial cell death signalling. Curc might be used as a combined therapy with continuous positive airway pressure in sleep apnoea patients with high cardiovascular risk.
Identifiants
pubmed: 32637058
doi: 10.1177/2040622320922104
pii: 10.1177_2040622320922104
pmc: PMC7315663
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2040622320922104Informations de copyright
© The Author(s), 2020.
Déclaration de conflit d'intérêts
Conflict of interest statement: The authors declare that there is no conflict of interest.
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