Feline infectious peritonitis virus-associated rhinitis in a cat.
Feline infectious peritonitis
feline coronavirus
nasal cavity
rhinitis
spike protein
Journal
JFMS open reports
ISSN: 2055-1169
Titre abrégé: JFMS Open Rep
Pays: England
ID NLM: 101672978
Informations de publication
Date de publication:
Historique:
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
9
7
2020
Statut:
epublish
Résumé
This report describes a cat with initial respiratory signs prior to developing fulminant feline infectious peritonitis (FIP) after adoption from an animal shelter. Histologic examination of the tissues revealed typical lesions associated with FIP in the lung, liver, large intestine and small intestine. Histologic examination of the nasal cavity revealed pyogranulomatous rhinitis. Immunohistochemistry with monoclonal antibody FIPV3-70 targeting FIP antigen in macrophages confirmed FIP and molecular analysis identified a spike protein mutation (R793S) consistent with the presence of an FIP virus. Pathological changes, immunolabeling and molecular analysis provide evidence that respiratory infection by feline coronavirus is part of the spectrum of FIP-associated disease. This report highlights nasal pathology associated with FIP through a combination of histopathology, immunohistochemistry and molecular characterization of the virus. Our work supports a little-appreciated role of the respiratory tract in FIP.
Identifiants
pubmed: 32637147
doi: 10.1177/2055116920930582
pii: 10.1177_2055116920930582
pmc: PMC7313338
doi:
Types de publication
Case Reports
Langues
eng
Pagination
2055116920930582Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Conflict of interest: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Références
Viruses. 2019 Nov 15;11(11):
pubmed: 31731711
Am J Vet Res. 1981 Dec;42(12):2036-48
pubmed: 6280518
Vet Pathol. 2014 Mar;51(2):505-26
pubmed: 24569616
J Gen Virol. 2010 Feb;91(Pt 2):415-20
pubmed: 19889934
Viruses. 2009 Sep;1(2):166-84
pubmed: 21994544
Acta Vet Scand. 1993;34(4):345-56
pubmed: 8147286
Vet J. 2014 Aug;201(2):133-41
pubmed: 24857253
JFMS Open Rep. 2019 Jun 26;5(1):2055116919856103
pubmed: 31534775
Emerg Infect Dis. 2013 Jul;19(7):1066-73
pubmed: 23763835
Emerg Infect Dis. 2012 Jul;18(7):1089-95
pubmed: 22709821