Aging and menopause reprogram osteoclast precursors for aggressive bone resorption.
Bone
Osteoporosis
Journal
Bone research
ISSN: 2095-4700
Titre abrégé: Bone Res
Pays: China
ID NLM: 101608652
Informations de publication
Date de publication:
2020
2020
Historique:
received:
16
01
2020
revised:
06
03
2020
accepted:
07
04
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
9
7
2020
Statut:
epublish
Résumé
Women gradually lose bone from the age of ~35 years, but around menopause, the rate of bone loss escalates due to increasing bone resorption and decreasing bone formation levels, rendering these individuals more prone to developing osteoporosis. The increased osteoclast activity has been linked to a reduced estrogen level and other hormonal changes. However, it is unclear whether intrinsic changes in osteoclast precursors around menopause can also explain the increased osteoclast activity. Therefore, we set up a protocol in which CD14
Identifiants
pubmed: 32637185
doi: 10.1038/s41413-020-0102-7
pii: 102
pmc: PMC7329827
doi:
Types de publication
Journal Article
Langues
eng
Pagination
27Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing interests.
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