Immobilization of Growth Factors for Cell Therapy Manufacturing.
cell product manufacturing
cell therapy
cost-of-goods
growth factor
immobilization
stem cell factor
Journal
Frontiers in bioengineering and biotechnology
ISSN: 2296-4185
Titre abrégé: Front Bioeng Biotechnol
Pays: Switzerland
ID NLM: 101632513
Informations de publication
Date de publication:
2020
2020
Historique:
received:
09
03
2020
accepted:
20
05
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
9
7
2020
Statut:
epublish
Résumé
Cell therapy products exhibit great therapeutic potential but come with a deterring price tag partly caused by their costly manufacturing processes. The development of strategies that lead to cost-effective cell production is key to expand the reach of cell therapies. Growth factors are critical culture media components required for the maintenance and differentiation of cells in culture and are widely employed in cell therapy manufacturing. However, they are expensive, and their common use in soluble form is often associated with decreased stability and bioactivity. Immobilization has emerged as a possible strategy to optimize growth factor use in cell culture. To date, several immobilization techniques have been reported for attaching growth factors onto a variety of biomaterials, but these have been focused on tissue engineering. This review briefly summarizes the current landscape of cell therapy manufacturing, before describing the types of chemistry that can be used to immobilize growth factors for cell culture. Emphasis is placed to identify strategies that could reduce growth factor usage and enhance bioactivity. Finally, we describe a case study for stem cell factor.
Identifiants
pubmed: 32637403
doi: 10.3389/fbioe.2020.00620
pmc: PMC7317031
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
620Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2020 Enriquez-Ochoa, Robles-Ovalle, Mayolo-Deloisa and Brunck.
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