Baclofen Toxicity in Children With Acute Kidney Injury: Case Reports and Review of the Literature.
baclofen
children
dystonia
kidney injury
rehabilitation
spasticity
traumatic brain injury
Journal
Child neurology open
ISSN: 2329-048X
Titre abrégé: Child Neurol Open
Pays: United States
ID NLM: 101691975
Informations de publication
Date de publication:
Historique:
received:
09
04
2020
revised:
15
05
2020
accepted:
27
05
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
9
7
2020
Statut:
epublish
Résumé
Baclofen is a medication used for tone management in cerebral palsy. Although it acts mainly at the spinal cord level, it can cause central nervous system adverse reactions at higher doses. Baclofen is mainly eliminated by renal excretion and there have been reports on adverse events when used in adults with renal impairment; however, there are no consensus guidelines as to the dose adjustments required due to renal impairment. The authors describe 2 children with acute kidney injury (AKI) and systemic side effects with initiation of oral baclofen, which was started for treatment of dystonia/spasticity in the recovery phase of their kidney injury. Following the initiation of the drug, they both had decreased level of consciousness and respiratory difficulties, which warranted discontinuation of the drug. These cases highlight the need for reduced initial dose, slow titration, and close monitoring when initiating baclofen treatment in children with AKI.
Identifiants
pubmed: 32637443
doi: 10.1177/2329048X20937113
pii: 10.1177_2329048X20937113
pmc: PMC7315666
doi:
Types de publication
Case Reports
Langues
eng
Pagination
2329048X20937113Informations de copyright
© The Author(s) 2020.
Déclaration de conflit d'intérêts
Declaration of Conflicting Interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
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