Unexpected Mutations by CRISPR-Cas9 CTG Repeat Excision in Myotonic Dystrophy and Use of CRISPR Interference as an Alternative Approach.

CRISPR interference CRISPR-Cas9 DMPK RNA foci genome editing myotonic dystrophy off-target

Journal

Molecular therapy. Methods & clinical development
ISSN: 2329-0501
Titre abrégé: Mol Ther Methods Clin Dev
Pays: United States
ID NLM: 101624857

Informations de publication

Date de publication:
11 Sep 2020
Historique:
received: 12 05 2020
accepted: 20 05 2020
entrez: 9 7 2020
pubmed: 9 7 2020
medline: 9 7 2020
Statut: epublish

Résumé

Myotonic dystrophy type 1 is the most common type of adult-onset muscular dystrophy. This is an autosomal dominant disorder and caused by the expansion of the CTG repeat in the 3' untranslated region of the dystrophia myotonica protein kinase (

Identifiants

pubmed: 32637445
doi: 10.1016/j.omtm.2020.05.024
pii: S2329-0501(20)30111-X
pmc: PMC7321784
doi:

Types de publication

Journal Article

Langues

eng

Pagination

131-144

Informations de copyright

© 2020 The Author(s).

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Auteurs

Miki Ikeda (M)

Department of Neurology, School of Medicine, Teikyo University, Tokyo 1738606, Japan.

Mariko Taniguchi-Ikeda (M)

Department of Clinical Genetics, Fujita Health University Hospital, Aichi 4701192, Japan.
Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Aichi 4701192, Japan.

Takema Kato (T)

Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Aichi 4701192, Japan.

Yasuko Shinkai (Y)

Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Aichi 4701192, Japan.

Sonoko Tanaka (S)

Department of Neurology, School of Medicine, Teikyo University, Tokyo 1738606, Japan.

Hiroki Hagiwara (H)

Department of Medical Science, Teikyo University of Science, Uenohara Campus, Yamanashi 4090193, Japan.

Naomichi Sasaki (N)

Department of Medical Science, Teikyo University of Science, Senju Campus, Tokyo 1200045, Japan.

Toshihiro Masaki (T)

Department of Medical Science, Teikyo University of Science, Senju Campus, Tokyo 1200045, Japan.

Kiichiro Matsumura (K)

Department of Neurology, School of Medicine, Teikyo University, Tokyo 1738606, Japan.

Masahiro Sonoo (M)

Department of Neurology, School of Medicine, Teikyo University, Tokyo 1738606, Japan.

Hiroki Kurahashi (H)

Division of Molecular Genetics, Institute for Comprehensive Medical Science, Fujita Health University, Aichi 4701192, Japan.

Fumiaki Saito (F)

Department of Neurology, School of Medicine, Teikyo University, Tokyo 1738606, Japan.

Classifications MeSH