Lysosomal recycling of amino acids affects ER quality control.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
25
10
2019
accepted:
13
05
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
9
7
2020
Statut:
epublish
Résumé
Recent work has highlighted the fact that lysosomes are a critical signaling hub of metabolic processes, providing fundamental building blocks crucial for anabolic functions. How lysosomal functions affect other cellular compartments is not fully understood. Here, we find that lysosomal recycling of the amino acids lysine and arginine is essential for proper ER quality control through the UPR
Identifiants
pubmed: 32637599
doi: 10.1126/sciadv.aaz9805
pii: aaz9805
pmc: PMC7319768
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eaaz9805Subventions
Organisme : NIA NIH HHS
ID : K99 AG065200
Pays : United States
Organisme : NIAMS NIH HHS
ID : F31 AR070013
Pays : United States
Organisme : NIH HHS
ID : P40 OD010440
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG042679
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG000266
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM130995
Pays : United States
Organisme : NIA NIH HHS
ID : R00 AG065200
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM122589
Pays : United States
Organisme : NIA NIH HHS
ID : F32 AG065381
Pays : United States
Organisme : NIA NIH HHS
ID : F31 AG055326
Pays : United States
Organisme : NIA NIH HHS
ID : R33 AG051047
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM127763
Pays : United States
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).
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