Chronic alcohol consumption alters extracellular space geometry and transmitter diffusion in the brain.
Journal
Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
28
10
2019
accepted:
14
05
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
9
7
2020
Statut:
epublish
Résumé
Already moderate alcohol consumption has detrimental long-term effects on brain function. However, how alcohol produces its potent addictive effects despite being a weak reinforcer is a poorly understood conundrum that likely hampers the development of successful interventions to limit heavy drinking. In this translational study, we demonstrate widespread increased mean diffusivity in the brain gray matter of chronically drinking humans and rats. These alterations appear soon after drinking initiation in rats, persist into early abstinence in both species, and are associated with a robust decrease in extracellular space tortuosity explained by a microglial reaction. Mathematical modeling of the diffusivity changes unveils an increased spatial reach of extrasynaptically released transmitters like dopamine that may contribute to alcohol's progressively enhanced addictive potency.
Identifiants
pubmed: 32637601
doi: 10.1126/sciadv.aba0154
pii: aba0154
pmc: PMC7314532
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
eaba0154Subventions
Organisme : NIDA NIH HHS
ID : F30 DA017447
Pays : United States
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
Références
Brain Sci. 2016 May 26;6(2):
pubmed: 27240410
Alcohol Clin Exp Res. 1999 Jan;23(1):164-8
pubmed: 10029219
Neuropsychopharmacology. 2005 Feb;30(2):423-32
pubmed: 15562292
Neurosci Biobehav Rev. 2019 Nov;106:141-164
pubmed: 30243576
Nat Commun. 2019 Aug 21;10(1):3758
pubmed: 31434879
Neuroimage. 2006 Jul 15;31(4):1487-505
pubmed: 16624579
Toxicol Lett. 2018 Feb;283:21-31
pubmed: 29129797
Sci Rep. 2018 Feb 2;8(1):2246
pubmed: 29396480
Addict Biol. 2017 Sep;22(5):1459-1472
pubmed: 27273582
Addict Biol. 2019 Aug 1;:e12816
pubmed: 31373129
Curr Top Behav Neurosci. 2013;13:251-69
pubmed: 22328453
Br Med J. 1964 Jul 18;2(5402):177
pubmed: 14150898
Neuropharmacology. 2017 Aug 1;122:56-73
pubmed: 28159648
Neuroimage. 2009 Jul 1;46(3):786-802
pubmed: 19195496
JAMA Psychiatry. 2019 Jul 1;76(7):749-758
pubmed: 30942831
Lancet. 2013 Nov 9;382(9904):1575-86
pubmed: 23993280
Trends Neurosci. 2004 May;27(5):270-7
pubmed: 15111009
Genes Brain Behav. 2017 Jan;16(1):86-100
pubmed: 27657733
Neurobiol Aging. 2010 Mar;31(3):482-93
pubmed: 18513834
Alcohol Clin Exp Res. 2005 May;29(5):746-55
pubmed: 15897718
Cell. 2013 Dec 19;155(7):1596-609
pubmed: 24360280
PLoS One. 2012;7(7):e41441
pubmed: 22829950
Synapse. 2006 Sep 1;60(3):251-5
pubmed: 16752364
Psychopharmacology (Berl). 2007 Sep;193(4):495-501
pubmed: 17492432
Acta Physiol (Oxf). 2009 Jan;195(1):101-10
pubmed: 18983449
Biophys J. 1995 May;68(5):1699-715
pubmed: 7612814
J Physiol. 1981 Dec;321:225-57
pubmed: 7338810
Sci Transl Med. 2012 Aug 15;4(147):147ra111
pubmed: 22896675
Biol Psychiatry. 2002 Dec 15;52(12):1121-33
pubmed: 12488057
Nat Methods. 2012 Jun 28;9(7):676-82
pubmed: 22743772
PLoS One. 2009 Aug 26;4(8):e6786
pubmed: 19707568
Physiol Rev. 2008 Oct;88(4):1277-340
pubmed: 18923183
BMJ. 2017 Jun 6;357:j2353
pubmed: 28588063
Neurosci Lett. 2002 Dec 16;334(3):157-60
pubmed: 12453619
Methods Mol Biol. 2013;1041:295-305
pubmed: 23813388
Alcohol Res. 2015;37(2):331-41, 344-51
pubmed: 26695754
Brain Behav Immun. 2011 Jun;25 Suppl 1:S92-S105
pubmed: 21266194
Addict Biol. 2006 Sep;11(3-4):339-55
pubmed: 16961763
Neuron. 2015 Dec 2;88(5):1054-1066
pubmed: 26586182
Alcohol Clin Exp Res. 2006 Nov;30(11):1845-55
pubmed: 17067348
Alcohol Clin Exp Res. 2016 Jul;40(7):1380-9
pubmed: 27223341
Physiol Rev. 2009 Apr;89(2):649-705
pubmed: 19342616
Neuroimage. 2014 Apr 1;89:35-44
pubmed: 24342225