4D physiologically adaptable cardiac patch: A 4-month in vivo study for the treatment of myocardial infarction.

Animals Bioengineering Mice Myocardial Infarction / therapy Myocardium Myocytes, Cardiac Regeneration Tissue Engineering / methods Tissue Scaffolds

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
06 2020
Historique:
received: 28 02 2020
accepted: 11 05 2020
entrez: 9 7 2020
pubmed: 9 7 2020
medline: 12 4 2022
Statut: epublish

Résumé

There has been considerable progress in engineering cardiac scaffolds for the treatment of myocardial infarction (MI). However, it is still challenging to replicate the structural specificity and variability of cardiac tissues using traditional bioengineering approaches. In this study, a four-dimensional (4D) cardiac patch with physiological adaptability has been printed by beam-scanning stereolithography. By combining a unique 4D self-morphing capacity with expandable microstructure, the specific design has been shown to improve both the biomechanical properties of the patches themselves and the dynamic integration of the patch with the beating heart. Our results demonstrate improved vascularization and cardiomyocyte maturation in vitro under physiologically relevant mechanical stimulation, as well as increased cell engraftment and vascular supply in a murine chronic MI model. This work not only potentially provides an effective treatment method for MI but also contributes a cutting-edge methodology to enhance the structural design of complex tissues for organ regeneration.

Identifiants

DOI: 10.1126/sciadv.abb5067 PMID: 32637623 PMC: PMC7314523
pubmed: 32637623
doi: 10.1126/sciadv.abb5067
pii: abb5067
pmc: PMC7314523
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

eabb5067

Subventions

Organisme : NIBIB NIH HHS
ID : DP2 EB020549
Pays : United States

Informations de copyright

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Auteurs

Haitao Cui (H)

Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA.
ORCID: 0000-0002-0641-6029

Chengyu Liu (C)

National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
ORCID: 0000-0002-5136-9225

Timothy Esworthy (T)

Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA.
ORCID: 0000-0002-0826-2860

Yimin Huang (Y)

National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Zu-Xi Yu (ZX)

National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Xuan Zhou (X)

Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA.

Hong San (H)

National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Se-Jun Lee (SJ)

Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA.
ORCID: 0000-0002-3906-9692

Sung Yun Hann (SY)

Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA.

Manfred Boehm (M)

National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892, USA.
ORCID: 0000-0002-2251-3638

Muhammad Mohiuddin (M)

Cardiac Xenotransplantation Program, Department of Surgery, University of Maryland, Baltimore, MD 21201, USA.

John P Fisher (JP)

Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, USA.
ORCID: 0000-0002-4019-348X

Lijie Grace Zhang (LG)

Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, DC 20052, USA.
Department of Electrical and Computer Engineering, The George Washington University, Washington, DC 20052, USA.
Department of Biomedical Engineering, The George Washington University, Washington, DC 20052, USA.
Department of Medicine, The George Washington University, Washington, DC 20052, USA.
ORCID: 0000-0003-3009-045X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › 4D physiologically adaptable cardiac patch: A...
questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › 4D physiologically adaptable cardiac patch: A...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › 4D physiologically adaptable cardiac patch: A...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus du myocarde › 4D physiologically adaptable cardiac patch: A...
questionsmedicales.fr › Tissus › Muscles › Muscle strié › Myocarde › 4D physiologically adaptable cardiac patch: A...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › 4D physiologically adaptable cardiac patch: A...
questionsmedicales.fr › Phénomènes biologiques › Régénération › 4D physiologically adaptable cardiac patch: A...
questionsmedicales.fr › Technologie, industrie et agriculture › Ingénierie › Bioingénierie › Ingénierie cellulaire › Ingénierie tissulaire › 4D physiologically adaptable cardiac patch: A...
questionsmedicales.fr › Équipement et fournitures › Prothèses et implants › Structures d'échafaudage tissulaires › 4D physiologically adaptable cardiac patch: A...