Metabolic engineering of a methyltransferase for production of drug precursors demecycline and demeclocycline in

Demeclocycline Demecycline Metabolic engineering Streptomyces aureofaciens F3

Journal

Synthetic and systems biotechnology
ISSN: 2405-805X
Titre abrégé: Synth Syst Biotechnol
Pays: China
ID NLM: 101694371

Informations de publication

Date de publication:
Sep 2020
Historique:
received: 25 02 2020
revised: 02 06 2020
accepted: 03 06 2020
entrez: 9 7 2020
pubmed: 9 7 2020
medline: 9 7 2020
Statut: epublish

Résumé

Demecycline (DMTC) and demeclocycline (DMCTC) are C6-demethylated derivatives of tetracycline (TC) and chlortetracycline (CTC), respectively. They are precursors of minocycline and tigecycline, which showed remarkable bioactivity against TC-resistant bacteria and have been used clinically for decades. In order to biosynthesize drug precursors DMTC and DMCTC, the function of a possible C-methyltransferase encoding gene

Identifiants

DOI: 10.1016/j.synbio.2020.06.001 PMID: 32637665 PMC: PMC7320239
pubmed: 32637665
doi: 10.1016/j.synbio.2020.06.001
pii: S2405-805X(20)30028-4
pmc: PMC7320239
doi:

Types de publication

Journal Article

Langues

eng

Pagination

121-130

Informations de copyright

© 2020 Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.

Déclaration de conflit d'intérêts

The authors declare no financial or commercial conflict of interest.

Références

J Am Chem Soc. 2008 May 14;130(19):6068-9
pubmed: 18422316
Microb Cell Fact. 2015 Apr 02;14:46
pubmed: 25886456
BMC Biotechnol. 2012 Aug 20;12:52
pubmed: 22906146
Clin Infect Dis. 2005 Sep 1;41 Suppl 5:S341-53
pubmed: 16080072
J Biol Chem. 2010 Sep 3;285(36):27509-15
pubmed: 20522541
Biochem Cell Biol. 2008 Apr;86(2):124-36
pubmed: 18443626
Neurobiol Dis. 2004 Dec;17(3):359-66
pubmed: 15571972
Cell Chem Biol. 2016 Apr 21;23(4):508-16
pubmed: 27105283
BMC Microbiol. 2019 Dec 10;19(1):279
pubmed: 31823730
Nat Prod Rep. 2012 Oct;29(10):1238-50
pubmed: 22850796
J Am Chem Soc. 1968 Apr 10;90(8):2201-2
pubmed: 5641578
J Mol Biol. 1999 Sep 17;292(2):195-202
pubmed: 10493868
Angew Chem Int Ed Engl. 2015 Mar 27;54(14):4226-30
pubmed: 25678465
Biotechnol Adv. 2019 Nov 1;37(6):107366
pubmed: 30853630
Gene. 1990 Sep 28;94(1):53-9
pubmed: 2227452
Ann N Y Acad Sci. 2011 Dec;1241:17-32
pubmed: 22191524
Br J Dermatol. 2003 Aug;149(2):237-9
pubmed: 12932226
J Med Chem. 1994 Jan 7;37(1):184-8
pubmed: 8289194
J Inorg Biochem. 1983 Aug;19(1):1-18
pubmed: 6619838
Bioorg Med Chem Lett. 2018 Jun 15;28(11):1992-1999
pubmed: 29731363
Biol Chem. 2014 May;395(5):559-75
pubmed: 24497223
ACS Chem Biol. 2018 Apr 20;13(4):1003-1012
pubmed: 29510028
Enzyme Microb Technol. 2011 Jun 10;49(1):17-24
pubmed: 22112266
J Mol Biol. 2006 Jul 21;360(4):839-49
pubmed: 16797589
Angew Chem Int Ed Engl. 2014 Aug 18;53(34):8840-69
pubmed: 24990531
Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):1541-6
pubmed: 12563033
Ann N Y Acad Sci. 1954 Oct 29;60(1):86-101
pubmed: 13229222
J Am Chem Soc. 2011 Dec 7;133(48):19346-9
pubmed: 22050348
Antimicrob Agents Chemother. 2000 Apr;44(4):943-9
pubmed: 10722495
J Biol Chem. 2007 Aug 31;282(35):25717-25
pubmed: 17631493
Metab Eng. 2017 Jan;39:228-236
pubmed: 28013086
Antimicrob Agents Chemother. 1975 Dec;8(6):713-20
pubmed: 1211925
Folia Microbiol (Praha). 1987;32(5):388-401
pubmed: 2891594
J Bacteriol. 1999 Jan;181(1):204-11
pubmed: 9864331
Angew Chem Int Ed Engl. 2012 Oct 29;51(44):11136-40
pubmed: 23024027
Antimicrob Agents Chemother. 1999 Apr;43(4):738-44
pubmed: 10103174
Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6640-5
pubmed: 10829079
Nucleic Acids Res. 2019 Jul 2;47(W1):W402-W407
pubmed: 31251384
Chembiochem. 2016 May 3;17(9):821-4
pubmed: 26840773
Med Clin North Am. 1995 Jul;79(4):789-801
pubmed: 7791423
Medicina (Kaunas). 2010;46(4):240-8
pubmed: 20571291
Front Microbiol. 2018 Feb 12;9:155
pubmed: 29483901
Br J Pharmacol. 2013 May;169(2):337-52
pubmed: 23441623
Int J Antimicrob Agents. 2011 Jun;37(6):562-6
pubmed: 21497066
Clin Infect Dis. 2005 Sep 1;41 Suppl 5:S354-67
pubmed: 16080073
Metab Eng. 2013 Sep;19:69-78
pubmed: 23800859
Chem Biol. 2009 May 29;16(5):567-76
pubmed: 19477421
J Med Chem. 1967 Jan;10(1):44-6
pubmed: 6031702
Cell. 2000 Dec 22;103(7):1143-54
pubmed: 11163189
Science. 1950 Jan 27;111(2874):85
pubmed: 15400447
Enzyme Microb Technol. 2012 May 10;50(6-7):318-24
pubmed: 22500899
Microbiology. 2013 Dec;159(Pt 12):2524-2532
pubmed: 24043447
Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W321-6
pubmed: 15215403
Ann N Y Acad Sci. 2011 Dec;1241:163-9
pubmed: 22191532
Biochim Biophys Acta. 1963 Apr 2;71:199-201
pubmed: 13937951

Auteurs

Weinan Yang (W)

State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200030, China.

Lingxin Kong (L)

State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200030, China.

Qing Wang (Q)

State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200030, China.

Zixin Deng (Z)

State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200030, China.

Delin You (D)

State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, 200030, China.

Classifications MeSH