Cell-free synthesis system-assisted pathway bottleneck diagnosis and engineering in
Bacillus subtilis
Cell-free synthesis system
Pathway bottleneck diagnosis
Journal
Synthetic and systems biotechnology
ISSN: 2405-805X
Titre abrégé: Synth Syst Biotechnol
Pays: China
ID NLM: 101694371
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
03
05
2020
revised:
12
06
2020
accepted:
15
06
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
9
7
2020
Statut:
epublish
Résumé
Metabolic engineering is a key technology for cell factories construction by rewiring cellular resources to achieve efficient production of target chemicals. However, the existence of bottlenecks in synthetic pathway can seriously affect production efficiency, which is also one of the core issues for metabolic engineers to solve. Therefore, developing an approach for diagnosing potential metabolic bottlenecks in a faster and simpler manner is of great significance to accelerate cell factories construction. The cell-free reaction system based on cell lysates can transfer metabolic reactions from
Identifiants
pubmed: 32637666
doi: 10.1016/j.synbio.2020.06.006
pii: S2405-805X(20)30032-6
pmc: PMC7320236
doi:
Types de publication
Journal Article
Langues
eng
Pagination
131-136Informations de copyright
© 2020 Production and hosting by Elsevier B.V. on behalf of KeAi Communications Co., Ltd.
Déclaration de conflit d'intérêts
The authors declare no competing financial interests.
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