Harnessing sub-organelle metabolism for biosynthesis of isoprenoids in yeast.
Compartmentalization
Isoprenoids
Sub-organelle metabolism
Yeast
Journal
Synthetic and systems biotechnology
ISSN: 2405-805X
Titre abrégé: Synth Syst Biotechnol
Pays: China
ID NLM: 101694371
Informations de publication
Date de publication:
Sep 2020
Sep 2020
Historique:
received:
08
04
2020
revised:
27
05
2020
accepted:
05
06
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
9
7
2020
Statut:
epublish
Résumé
Current yeast metabolic engineering in isoprenoids production mainly focuses on rewiring of cytosolic metabolic pathway. However, the precursors, cofactors and the enzymes are distributed in various sub-cellular compartments, which may hamper isoprenoid biosynthesis. On the other side, pathway compartmentalization provides several advantages for improving metabolic flux toward target products. We here summarize the recent advances on harnessing sub-organelle for isoprenoids biosynthesis in yeast, and analyze the knowledge about the localization of enzymes, cofactors and metabolites for guiding the rewiring of the sub-organelle metabolism. This review may provide some insights for constructing efficient yeast cell factories for production of isoprenoids and even other natural products.
Identifiants
pubmed: 32637671
doi: 10.1016/j.synbio.2020.06.005
pii: S2405-805X(20)30031-4
pmc: PMC7332497
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
179-186Informations de copyright
© 2020 KeAi Communications Co.(+) Ltd.
Déclaration de conflit d'intérêts
The authors declare no commercial or financial conflict of interest.
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