Regulation of the Viscoelastic Properties of Hyaluronate-Alginate Hybrid Hydrogel as an Injectable for Chondrocyte Delivery.
Journal
ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658
Informations de publication
Date de publication:
30 Jun 2020
30 Jun 2020
Historique:
received:
16
04
2020
accepted:
03
06
2020
entrez:
9
7
2020
pubmed:
9
7
2020
medline:
9
7
2020
Statut:
epublish
Résumé
Modulation of the viscoelastic properties of hydrogels is critical in tissue engineering applications. In the present study, a hyaluronate-alginate hybrid (HAH) was synthesized by introducing alginate to the hyaluronate backbone with varying molecular weights (700-2500 kDa), and HAH hydrogels were prepared in the presence of calcium ions at the same cross-linking density. The storage shear moduli of the HAH hydrogels increased with the concomitant increase in the molecular weight of hyaluronate in the HAH polymer. The HAH hydrogels were also modified with arginine-glycine-aspartic acid (RGD) and histidine-alanine-valine (HAV) peptides to enhance cell-matrix and cell-cell interactions, respectively. The chondrogenic differentiation of ATDC5 cells encapsulated within the HAH hydrogels was enhanced with the increase in the storage shear moduli of the gels
Identifiants
pubmed: 32637832
doi: 10.1021/acsomega.0c01763
pmc: PMC7331060
doi:
Types de publication
Journal Article
Langues
eng
Pagination
15567-15575Informations de copyright
Copyright © 2020 American Chemical Society.
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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